"Bioss"

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C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of _-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.

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Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.

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May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.

Supplier: Bioss

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

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The endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and SH3P13, respectively. These proteins associate with Amphiphysin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse, as Endophilin I is ex- pressed only in the brain. Both Endophilin II and Endophilin III are detected in a variety of tissues. Endophilin I is also implicated in modulating G protein-coupled receptor signaling by functioning as an adapter protein and directing 1 adrenergic receptors to the endocytic machinery.

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This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].

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DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.

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TREM2 POLYCLONAL ANTIBODY RABBIT 1 * 20 µl

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SYNDECAN 1 POLYCLONAL ANTIBODY, APC-CY7 CONJUGATED 1 * 1 items

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DAT1 POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: IF(IHC- P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

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BNP(H1G3) MONOCLONAL ANTIBODY, ALEXA FLUOR® 750 CONJUGATED, HOST: MOUSE, CROSS REACTIVE SPECIES: HUMAN, APPLICATION: IF(IHC-P), CONC ENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

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TSPAN15 POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: FCM, IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

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AMIGO3 POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, APPLICATION: IF(IHC-P), CONCEN TRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

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HBSAG(H2F4) MONOCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: MOUSE, CROSS REACTIVE SPECIES: VIRUS, APPLICATION: IF(IHC-P), CO NCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

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AIF1 Polyclonal Antibody, AbBy Fluor® 405 Conjugated 1 * 100 µl

Supplier: Bioss

STATHMIN 1 (SER24) POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLIC ATION: IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl