"BML-111&amp"

Supplier: Enzo Life Sciences

A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).

Supplier: Enzo Life Sciences

HDAC inhibitor developed at Enzo Life Sciences. Inhibits HDAC activity in HeLa nuclear extracts (IC50=5-10µM).

Supplier: Enzo Life Sciences

Potent and selective inhibitor of phospholipase D2 (PLD2) in cellular (PLD1 IC50 = 1900nM Calu-1 cells; PLD2 IC50 = 90nM HEK293-gfpPLD2 cells) and in vitro (hPLD1 IC50 = >20’000nM; hPLD2 IC50 = 500nM) assays.

Supplier: Abcam

Highly potent, cell-permeable inhibitor of cathepsin K (IC₅₀ = 51 nM). Cell permeable and orally active.

Supplier: Abcam

Histone deacetylase (HDAC) inhibitor (IC₅₀ =87 μM). Induces changes in gene expression profile. Antiproliferative activity in vitro.

Supplier: Apollo Scientific

BML-277

Supplier: Abcam

Potent, cell-permeable SIRT activator. Shows selectivity for SIRT1. Induces cell cycle arrest at G1/S phase.

Supplier: Enzo Life Sciences

BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.

Supplier: Abcam

Potent dual PLD1 and PLD2 inhibitor (IC₅₀ values are 8 and 42 nM for PLD1 and PLD2 respectively).

Supplier: Abcam

Potent, selective phosphodiesterase Type II (PDE2) inhibitor (IC₅₀ =40 nM). Demonstrates no inhibition of 5-lipoxygenase (5-LO) or cyclooxygenase (COX-1).

Supplier: Abcam

Potent, selective PLD2 inhibitor (IC₅₀ values are 90 and 500 nM for HEK293 and human cells respectively).

Supplier: Abcam

Cell-permeable Wnt signaling activator. Induces β-catenin and TCF-dependent transcriptional activity (EC₅₀ = 0,7 μM). Activates Wnt without inhibiting GSK-3β.Shows developmental effects in vivo.

Supplier: Apollo Scientific

1,1,1-Tribromotrifluoroacetone

Supplier: Apollo Scientific

1,1,1-Triphenylsilanamine

Supplier: Merck

AMP (2-Amino-2-methylpropanol) for synthesis, Sigma-Aldrich®

Supplier: Apollo Scientific

1,1,1-Trifluoropropane 97%