111966 Results for: "3-Fluorobenzyl+isothiocyanate&pageNo=10&view=easy"

Supplier: Honeywell Safety

SLEEVES HYPALON 1 * 1 items

Supplier: ENVIROFALK PHARMAWATERSYSTEMS

FILTER ACTIVE CARBON 20'' ELEMENT 10UM 1 * 1 items

Supplier: Testo

FILTER 325 1 * 1 items

Supplier: Ambion

Poly(A+)Mouse Embryo RNA 1 * 5 µG

Supplier: STEMCELL Technologies

Interleukin 6 (IL-6) is a pleiotropic growth factor with a wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Nordan et al.; Van Snick et al.; Gauldie et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of the JAK/STAT signaling pathway (Mihara et al.; Peters et al; Tanaka et al.).

Supplier: STEMCELL Technologies

Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau et al.). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Supplier: MACHEREY-NAGEL

TLC precoated plates CEL 300-25 size: 10x20 cm pack of 50 1 * 50 items

Supplier: BROWN CHROMATOGRAPHY SUPPLIES

[EN]SERUM BOTTLES TYPE 1 CLEAR GLASS 1 * 168 ST

Supplier: MARKET SOURCE PART PROCESS

20ML ND18 HEADSPACE SCREW VIAL (CLEAR), 75.5 X 22.5MM, ROUNDED BOTTOM, PK.100 1 * 100 ST

Supplier: Ambion

Total Mouse Embryo RNA 1 * 200 µG

Supplier: BUCHI

Last Flask For 5ML Ball Tube 1 * 1 items

Supplier: MARKET SOURCE PART PROCESS

10ML ND18 HEADSPACE SCREW VIAL (CLEAR), 46 X 22.5MM, ROUNDED BOTTOM, PK.100 1 * 100 ST

Supplier: Mettler - Toledo

This convenient, reliable instrument is suitable for complex applications and stringent requirements in regulated markets as well as for routine measurement tasks in laboratories. It offers various conductivity-based measurement parameters and can also be modularly expanded with additional measurement parameters at any time.

Supplier: PFM Medical GmbH

The high performance fully-electronic rotary microtome 3006 EM is suitable for all applications in routine use, research and industry. Excellent section quality, safe and simple operation and easy cleaning and care describe this microtome. The handwheel of Rotary 3006 EM has a removable handle to ensure maximum user safety during motorised sectioning. Additionally, the device can be stopped immediately by pushing the emergency stop button.

Supplier: Mettler - Toledo

This single-channel instrument can easily handle the most complex applications and meets stringent requirements in regulated markets. The meter is flexible and can be modularly expanded with additional measurement parameters at any time. Special methods for the most common incremental ion measurement techniques are included, such as standard addition, subtraction and sample addition and subtraction methods.

Supplier: STEMCELL Technologies

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra, the high-affinity receptor for IL-15, as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naive CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.).

Supplier: Portwest

Made from the highest quality cotton, this contemporary style offers exceptional all day comfort. Hardwearing, functional and packed full of features including: Top loading pre-shaped knee pad pockets, triple stitched seams, crotch gusset to reduce stress and prevent seam failure, adjustable leg length and a side leg cargo pocket. Strong Oxford fabric is positioned in key abrasion areas to offer extra durability.

Supplier: ProSci Inc.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. COX10 is heme A: farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Supplier: STEMCELL Technologies

Oncostatin M (OSM) is a member of interleukin 6 (IL-6) family of cytokines and bears close resemblance to leukemia inhibitory factor (LIF) and granulocyte colony-stimulating factor (G-CSF) in amino acid sequence and its modulation of differentiation in a variety of cell types (Rose and Bruce). OSM signals through type I receptor (consisting of gp130 and LIF receptor [LIFR]) and type II receptor (consisting of gp130 and OSM receptor [OSMR]), which eventually activate the JAK/STAT pathway (Auguste et al.; Gómez-Lechón). OSM is primarily produced by activated T cells and monocytes, and also by activated macrophages, neutrophils, mast cells, and dendritic cells. OSM is also produced within the bone microenvironment by cells of both hematopoietic and mesenchymal origin, including osteocytes and osteoblasts. OSM is involved in differentiation, cell proliferation, hematopoiesis, and inflammation, and also has been shown to have implications in liver development and bone formation and resorption (Sims and Quinn; Tanaka and Miyajima). This product is animal component-free.

Supplier: STEMCELL Technologies

Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau et al.). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Supplier: Showa

SHOWA CS720 full nitrile coated chemical protective glove Type A with rough finish extra coating on hand on seamless PEster/nylon liner Contact heat resistance level 1 size 11/XXL 1 * 60 PAIR

Supplier: ZWIEBEL

BRASS MASS 10G WITH CERTIFICATE 1 * 1 items

Supplier: ISOPAD

HEIZBAND SILIKON SIS10 1.5M 150W 1 * 1 ST

Supplier: DELTALAB

VACUUM PIPETTE GREEN 1 * 1 items

Supplier: EPPENDORF

PISTON 0,5-10UL 1 * 1 items

Supplier: MACHEREY-NAGEL

NucleoSpin RNA Plant and Fungi (50) 50 preps for the isolation of RNA from plant and fungi - NucleoSpin RNA Plant Columns, NucleoSpi n Plant Filters, Collection Tubes, buffers no dangerous goods according transport regulations 1 * 50 items

Supplier: Sartorius Balances

The Cubis® II range has a modular design that to allows the customer to choose the components that suit the application area that is of interest. For the customer, this configurable concept delivers quality weighing, together with a high degree of flexibility, without having to invest in expensive equipment that has features that may never be required.

Supplier: TECHNI GLOVE

Nitrile GL30cmTechniGlove TN1201W tacky Size S 1 * 1.000 items

Supplier: MOINEAU

MULTIMETER DIGITAL 932SI TRUE RMS 1 * 1 items

Supplier: Ambion

Total Rat Embryo RNA 1 * 200 µG