159409 Results for: "3-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic+acid"

Supplier: Bioss

Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity.PPAPDC3, also known as nuclear envelope transmembrane protein 39 (NET39), was initially discovered in an in silico screen for secreted or membrane proteins. It is a member of the PAP2 superfamily of phosphatases and haloperoxidases. PPAPDC3 has recently been shown to act as a negative regulator of myoblast differentiation by diminishing the activity of the mammalian target of rapamycin TOR. PPAPDC3 is highly expressed in cardiac and skeletal muscle and becomes strongly upregulated during cultured myoblast differentiation tissues. Overexpression of PPAPDC3 in myoblasts repressed myogenesis while knockdown by RNA interference promoted differentiation indicating its part in the regulatory mechanism for myogenesis.

Supplier: Merck

MQuant® (MQ) test strips can be considered as a mobile laboratory on a few square millimeters of plastic strip. As a screening method they provide the user with a rapid overview of the situation, which helps in making the choice of what, and perhaps if, further analysis is required, thereby leading to potentially substantial savings in time and analytical resources. The strip is a biologically-degradable polyester foil and the low reagent content, in the reaction zones, assists problem-free waste disposal.

Supplier: Merck

MQuant® (MQ) test strips can be considered as a mobile laboratory on a few square millimeters of plastic strip. As a screening method they provide the user with a rapid overview of the situation, which helps in making the choice of what, and perhaps if, further analysis is required, thereby leading to potentially substantial savings in time and analytical resources. The strip is a biologically-degradable polyester foil and the low reagent content, in the reaction zones, assists problem-free waste disposal.

Supplier: Cytiva (Formerly Pall Lab)

The AcroPrep™ Advance filter plate portfolio includes a variety of membrane types and pore sizes to provide the best possible performance for a wide range of sample preparation and high throughput screening applications. AcroPrep™ Advance filter plates are ideal for concentration, purification and desalting of proteins and peptides; bead and chromatography resin-based applications, gross fractionation and lysate clarification and general filtration.

Supplier: LGC Standards PROMOCHEM

APIXABAN 1 * 100 mg

Supplier: Bioss

TACC1 is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner

Supplier: Thermo Fisher Scientific

PS. Developed to bind compounds covalently to plastic surfaces. For use with molecules which do not adsorb easily to a traditional surface. Framed modules with alphanumeric orientation (external dimensions: 128×86 mm) fit all standard equipment.

Supplier: UVEX

These chemical protection gloves are made from butyl rubber with a Viton® outer layer.

Supplier: MAPA

These fluoroelastomer gloves with textile lining are recommended for prolonged contact with aromatic solvents, sulphur-based chemicals and amines.

Supplier: MAPA

Liquid-proof latex glove with smooth or textured finish. Ideal for use in wet conditions.

Supplier: UVEX

These chemical protection gloves feature a thick cotton interlock lining and a full NBR coating (nitrile rubber). This makes the uvex rubiflex S suitable for many applications in which protection against chemicals and increased mechanical protection (for example against heat) is required.

Supplier: Marigold (Ansell)

These electrical insulating gloves are made from 100% natural rubber latex using a proprietary environmentally friendly dipping process for ultimate flexibility and dexterity.

Supplier: Antibodies.com

Mouse D-Dimer ELISA Kit is a competitive Enzyme-Linked Immunosorbent Assay designed for the in vitro quantitative determination of mouse D-Dimer in plasma.

Supplier: HEATHROW

Sterile strips of semi-transparent, flexible, thermoplastic film with two-way stretch.

Supplier: Ansell

Medium-duty chemical barrier, Type 5/6 protection.

Supplier: Thermo Fisher Scientific

The Acclaim™ Trinity™ P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications, such as simultaneous separation of pharmaceutical drug substances and their counterions.

Supplier: Antibodies.com

Salbutamol ELISA Kit is a competitive Enzyme-Linked Immunosorbent Assay (cELISA) designed for the in vitro quantitative determination of Salbutamol in feed, tissue, urine.

Supplier: ProSci Inc.

PPAPDC3 Antibody: PPAPDC3, also known as nuclear envelope transmembrane protein 39 (NET39), was initially discovered in an in silico screen for secreted or membrane proteins. It is a member of the PAP2 superfamily of phosphatases and haloperoxidases. PPAPDC3 has recently been shown to act as a negative regulator of myoblast differentiation by diminishing the activity of the mammalian target of rapamycin TOR. PPAPDC3 is highly expressed in cardiac and skeletal muscle and becomes strongly upregulated during cultured myoblast differentiation tissues. Overexpression of PPAPDC3 in myoblasts repressed myogenesis while knockdown by RNA interference promoted differentiation indicating its part in the regulatory mechanism for myogenesis.

Supplier: Avantor

Crystals. Lot analysis on label.

Supplier: Corning

Axygen MaxyClear polypropylene microcentrifuge tubes feature exceptional clarity without compromising on strength.

Supplier: ProSci Inc.

Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.

Supplier: Antibodies.com

Olaquindox ELISA kit is a competitive Enzyme-Linked Immunosorbent Assay (cELISA) designed for the in vitro quantitative determination of Olaquindox in tissue and feed.

Supplier: Merck

All Spectroquant® test kits can be used with the Prove range of spectrophotometers and Nova 60/60A instruments. Tests can be used not only on photometers and spectrophotometer from Merck, but also on photometers and spectrophotometers from other suppliers (programming details available on request). Spectroquant® cell test kits.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: Biotium

The most sensitive DNA gel stain available in convenient pre-coated agarose format with no need for post-electrophoresis staining.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: KIMBERLY CLARK

WypAll® L10 professional wiping paper products are designed for the specific environments where they will be used, helping enable you to deliver on your wiping task every time.

Supplier: Merck

Optimized for the concentration and recovery of genomic DNA with SDS buffer. The low nonspecific binding characteristics of the membrane and the other device components, coupled with its medical-grade O-ring seal, allow the device to accommodate several wash steps with minimal sample loss.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: VWR Collection

50 µm polyolefin films with 50 µm inert encapsulated silicone adhesive. Especially suited for qPCR, storage and protein crystallisation applications. The encapsulated silicone adhesive is non tacky until pressed against the sealing surface, at which time adhesive is released only in sealing areas to form the strongest available heat resistant seal around each well on the plate.