111963 Results for: "2-(Butylamino)benzonitrile&pageNo=10&view=easy"

Supplier: BIOZYM

QUICKRACK 10X96 SP. 10µL MICROEXT FARBL 1 * 960 ST

Supplier: Aesculap

OSTEOTOM N.STILLE, GER., 10MM BR., 205MM 1 * 1 ST

Supplier: WATERS

COLUMN ORB SAX 80Å 10µM 4.6M 1 * 1 items

Supplier: Ambion

Total Mouse Embryo RNA 1 * 200 µG

Supplier: BUCHI

Last Flask For 5ML Ball Tube 1 * 1 items

Supplier: Sartorius Balances

The Cubis® II range has a modular design that to allows the customer to choose the components that suit the application area that is of interest. For the customer, this configurable concept delivers quality weighing, together with a high degree of flexibility, without having to invest in expensive equipment that has features that may never be required.

Supplier: ProSci Inc.

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.

Supplier: STEMCELL Technologies

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.).

Supplier: STEMCELL Technologies

Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).

Supplier: STEMCELL Technologies

Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro et al.). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao et al.). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya et al.). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi et al.; Miyagawa al.; Saito et al.).

Supplier: GERHARDT

PVC-TUBE 10X1MM L=400MM 1 * 1 items

Supplier: BIGNEAT

HPL Flat Base, 800mm wide 1 * 1 items

Supplier: Merck Millipore (Calbiochem‎)

1-Oleoyl-2-Acetyl-Sn-Glycerol (1Set = 10X500Ug) 1 * 1 SET

Supplier: WATERS

IC-PAK ANION-EXCHANGE GUARD-PAK INSERT 1 * 1 items

Supplier: IKA

PLATE FOR VMS-C10 1 * 1 items

Supplier: Abnova

Recombinant protein, npy1r (aah71720.1) recombinant protein without tag. 1 * 2 µG

Supplier: GERING

HYDROMETER BAUME 0-5 0,1 15C 1 * 1 items

Supplier: Abnova

Recombinant protein, cd7 (np_006128.1) recombinant protein without tag. 1 * 2 µG

Supplier: Abnova

Recombinant protein, cd97 (np_001775.2) recombinant protein without tag. 1 * 2 µG

Supplier: ZWIEBEL

SINGLE WEIGHT MADE OF CAST-IRON 10KG 1 * 1 items

Supplier: Roth Carl

SYRINGE REACTORS FOR PEPTIDE SYNTHESIS 1 1 * 100 items

Supplier: KNITTEL

COVER GLASSES ROUND 10MM A 1 * 1.000 items

Supplier: Honeywell Chemicals

Sodium pyrophosphate tetrabasic decahydrate 1 * 500 g

Supplier: VACUUBRAND

Pirani-Controller CVC 3000 Set with KF DN 16, for example for RE/RZ 2.5 and RE/RZ 6 with VSP 3000, Vacuum-Valve VV-B 15C, T-Connection, SW DN 15 and more connection parts 1 * 1 SET

Supplier: VWR Collection

This user friendly portable instrument with robust IP 67 rated housing provides high resolution and accuracy for precise measurements of pH, mV, conductivity and oxygen in field applications (can only be used to measure any two of these at the same time). Complete with waterproof USB output for connection to a computer. GLP compliant.

Supplier: Roth Carl

VIAL WITHOUT SNAPCAP 10ML 1 * 100 items

Supplier: Agilent

Syringe 10Ul Rn 23Ga. 1 * 1 items

Supplier: Socorex Isba

BARREL ASSEMBLY 10µL 1 * 1 items

Supplier: Ambion

dNTPs for cDNA Probe Synthesis 1 * 300 µl

Supplier: GERHARDT

ISOVERSINIC TUBING 12/17 ISO 1 * 1 m