90022 Results for: "1-[alpha-(4,6-Dimethoxypyrimidin-2-yl)benzyl]piperazine"

Supplier: Alpha Laboratories

DEEP WELL PLATE, 1.2ML, PP, STERILE 1 * 24 items

Supplier: Alpha Laboratories

MICRO CAPILLARY TIPS, 1-200UL STERILE 1 * 1.020 items

Supplier: 3M

CHEMICAL SORBENT ROLL 96CMX46M 1 * 1 Roll

Supplier: Alpha Packaging

Radiation/radioactive waste bag clear boxed, 455x760mm pk/50 1 * 50 items

Supplier: Alpha Laboratories

FREEZER RACK GREEN FOR 1.5/2.0ML µTUBE, 1 * 5 items

Supplier: Alpha Laboratories

FREEZER RACK ORANGE FOR 1.5/2.0ML µTUBE, 1 * 5 items

Supplier: WATERS

XSELECT CSH C18 3.5ΜM 4.6X100MM COLUMN 1 * 1 items

Supplier: Alpha Laboratories

SAMPLETITE PRIME JAR 120ML CLEAR NS 1 * 500 items

Supplier: Alpha Laboratories

9 inch non graduated Pastette®, length = 225mm, 25 drops per mL, non sterile, food grade LDPE. 1 * 400 items

Supplier: Alpha Laboratories

1ml Pasteur pipette, grad 0.25ml div, 155mm, 500 sterile 1s 1 * 500 items

Supplier: ACRO Biosystems

Mouse ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-M52W4) is expressed from human 293 cells (HEK293). It contains AA Phe 23 - Thr 1118 (ITGA10) & Gln 21 - Asp 728 (ITGB1) (Accession # E9PXZ3-1 (ITGA10) & P09055-1 (ITGB1)). 1 * 100 µG

Supplier: ACRO Biosystems

Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (IT1-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Pro 1041 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1) (Accession # XP_005571182.1 (ITGA7X1B) & A0A2K5WHU8-1 (ITGB 1 * 100 µG

Supplier: Alpha Laboratories

PASTEUR PIPET DUAL BULB, 100µL 1 * 5.000 items

Supplier: Alpha Laboratories

PASTEUR PIPET DUAL BULB, 250µL 1 * 5.000 items

Supplier: Alpha Laboratories

GRADUATED PASTETTE 3ML STERILE (50X10) 1 * 500 items

Supplier: Alpha Laboratories

9 inch standard Pasteurpipette, 225mm, 400 sterile 1s 1 * 400 items

Supplier: Alpha Laboratories

1-200µL GEL LOADING PIPETTORTIP NATURAL 1 * 1.000 items

Supplier: Roth Carl

a+ß-Thujone (isomers) 1 * 5 g

Supplier: Chemicon

cAMP-Dependent Protein Kinase Regulatory Subunit IIalpha [PKA RIIalpha... 100UG 1 * 100 µG

Supplier: Agilent

POROSHELL 120,EC-C18,2.1X50MM,2.7UM 1 * 3 items

Supplier: Alpha Laboratories

Extended fine tip mini Pasteur pipette, 104mm 400 sterile 1s 1 * 1 items

Supplier: Alpha Laboratories

LidLift-Off for 96-Position Combirack Natural Autoclavable Compatible with Combirack for 0.5ml 1.5ml and 2.0ml Microcentrifuge Tubes 1 * 5 items

Supplier: Roth Carl

A-CHLORALOSE 1 * 100 g

Supplier: Alpha Laboratories

Comb 24 well 0.35mm for 20cm Seq. unit 1 * 1 items

Supplier: Alpha Laboratories

SCREW CAP APEX GREEN NS PK OF 500 1 * 500 items

Supplier: Alpha Laboratories

PIERCEABLE MAT COVER, NON-STERILE FOR 1. 1 * 24 items

Supplier: Alpha Laboratories

PASTEUR PIPETTE 1ML, SMALL BULB, STER/20 1 * 500 items

Supplier: Alpha Laboratories

1-200µL GEL LOADING PIPETTOR TIP NATURAL 1 * 960 items

Supplier: Bioss

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.

Supplier: Alpha Packaging

ZIP BAG write on sample bag, re-sealable, 110x137mm, pk1000 1 * 1.000 items