27377 Results for: "(Z)-3-Bromoacrylic+acid&pageNo=87"

The heat shock proteins were discovered, as the name suggests, since they are heavily upregulated when cells are stressed by temperatures above the normal physiological range. They are expressed in unstressed cells also and have a normal function as chaperones, helping other proteins to fold correctly, and are required in much greater amounts if the cell or tissue is stressed by heat. The increased levels are generated transcriptionally under the influence of a powerful transcription factor, the heat shock factor 1 (HSF1). The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP27 has an apparent molecular weight of 27kDa. It is an abundant protein even under non-stress conditions and frequently shows up as a major spot on 2 dimensional gels of cells or tissues. It is known to associate with a variety of other proteins such as actin, intermediate filament subunits and ubiquitin and is found both in the cytoplasm and the nucleus of cells. HSP27 can become heavily phosphorylated under the influence of multiple protein kinases particularly as a result of activation of the p38/SAPK pathway. Upregulation of this protein is protective against neurodegenerative diseases at least in certain mouse models (1). Point mutations in the HSP27 gene are associated with two neurological diseases, Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy IIB (2). These diseases are associated with axonal loss apparently following defects in the transport of neurofilaments.

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Anti-Interleukin 27 Receptor alpha Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-Interleukin 27 Receptor alpha Rabbit Polyclonal Antibody

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Anti-Cox-17 Rabbit Polyclonal Antibody [clone: N8]

Supplier: Bioworld Technology

Synthetic peptide, corresponding to the N-terminal of Human Cox-17.

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Anti-Ku-80 Rabbit Polyclonal Antibody [clone: A717]

Supplier: Bioworld Technology

Synthetic peptide, corresponding to amino acids 690-730 of Human Ku-80.

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Label printers, bench top, BBP™35 and BBP™37

Supplier: Brady

The BBP™35 and BBP™37 sign and label printers with 300 dpi print resolution can produce signs and labels in the colours and shapes that can make a strong visual impact in the workplace.

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Silver ≥99.9% (metals basis), flakes 80% <20 µm

Supplier: Thermo Fisher Scientific

Silver ≥99.9% (metals basis), soluble 80% <20 µm

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2,4-Dichloro-6,7-dimethoxyquinazoline ≥98.0% (by HPLC, total nitrogen)

Supplier: TCI

2,4-Dichloro-6,7-dimethoxyquinazoline ≥98.0% (by HPLC, total nitrogen)

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Buffer, EDTA buffer solution pH 8,0 (0,5 mol/L)

Supplier: Rockland Immunochemicals

EDTA is widely used for scavenging metal ion in biochemistry and molecular biology. Ion depletion is commonly used to deactivate metal-dependent enzymes, either as an assay for their reactivity or to suppress damage to DNA or proteins.

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Anti-IgG3 Mouse Monoclonal Antibody [clone: PPV-07]

Supplier: Abcam

Mouse IgG3, monoclonal [PPV-07] - Isotype Control.

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Anti-HIV1 p17 Mouse Monoclonal Antibody [clone: 17-1]

Supplier: Abcam

Mouse monoclonal [17-1] to HIV1 p17.

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Hydriodic acid 57% (w/w) in aqueous solution unstabilised for analysis, distilled

Supplier: Thermo Fisher Scientific

Hydriodic acid 57% (w/w) in aqueous solution unstabilised for analysis, distilled

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4,7-Bis(5-trimethylstannyl-2-thienyl)-2,1,3-benzothiadiazole ≥95.0% (by GC)

Supplier: TCI

4,7-Bis(5-trimethylstannyl-2-thienyl)-2,1,3-benzothiadiazole ≥95.0% (by GC)

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Anti-ACTH Mouse Monoclonal Antibody (CF594) [clone: 57]

Supplier: Biotium

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.