71220 Results for: "(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl+chloride"

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Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V (D)J recombination.The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V (D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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The Defender 5000 series multifunctional bench scales are ideal for numerous applications including production, packaging, inventory and shipping. Durably constructed to withstand harsh environments and equipped with a stainless steel platform, stainless steel frame and a stainless steel (single range models) or aluminium load cell (dual range models).

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Receptors for the Fc region of immunoglobin G (Fc gamma R) are divided into three classes and Fc gamma RIII is a multifunctional, low/intermediate affinity receptor. In humans, Fc gamma RIII is expressed as two distinct forms (Fc gamma RIIIA and Fc gamma RIIIB) that are encoded by two different but highly homologous genes in a cell type-specific manner. Fc gamma RIIIB is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas Fc gamma RIIIA is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. The Fc gamma RIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. Fc gamma RIIIA has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. Aberrant expression or mutations in this gene is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. In humans, it is a 50 -70 kD type I transmembrane activating receptor. The Fc gamma RIIIA cDNA encodes 254 amino acid including a 16aa signal sequence, 191 amino acid ECD with two C2-type Ig-like domains, five potential N-glycosylation sites, a 22 amino acid transmembrane sequence and a 25 amino acid cytoplasmic domain.

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CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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Eppendorf Fast PCR tube strips made of polyethylene transfer heat faster than tubes made of traditional plastics. The Fast PCR tube strips are particularly suited to scientists using Fast PCR reagent kits, scientists trying to speed up protocols or cyclers with high heating and cooling rates.

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COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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Ambidextrous cleanroom gloves with beaded cuffs. Suitable for double donning.

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These ambidextrous nitrile gloves with beaded cuffs provide good resistance against chemicals. They also have excellent ESD properties.

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The Defender 5000 Series multifunctional bench scales are ideal for numerous applications including production, packaging, inventory and shipping. Durably constructed to withstand harsh environments and equipped with a stainless steel platform, powder-coated steel frame and an aluminium load cell. Choice of indicator: D52P unit is ABS plastic and the D52XW indicator is 304 stainless steel with sand blasted surface treatment, which offers protection to IP 68.

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The Defender 5000 series multifunctional bench scales are ideal for numerous applications including production, packaging, inventory and shipping. Durably constructed to withstand harsh environments and equipped with a stainless steel platform, stainless steel frame and a stainless steel (single range models) or aluminium load cell (dual range models). The front mounted D52XW indicator is 304 stainless steel with sand blasted surface treatment, which offers protection to IP 68.

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Dry and concentrate aqueous or non-aggressive samples with speed and efficiency with Thermo Scientific™ Savant SPD1030 and SPD2030 integrated SpeedVac™ systems and kits.

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Human SLC6A8 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human SLC6A8 in tissue homogenates or other biological fluids.

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Human KCC4 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human KCC4 in tissue homogenates or other biological fluids.

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These hand-specific nitrile gloves with beaded cuffs provide good resistance against chemicals. They also have excellent ESD properties.

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10 COMPONENTS MIX 1 * 5 Ampoul

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Integrin alpha5 (P1D6) mouse monoclonal IgG3 200 µg/ml raised against lymphokine activated killer cells 1 * 1 mL

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Integrin alpha2 (P1H5) mouse monoclonal IgG2b 200 µg/ml raised against HT1080 fibrosarcoma cells of human origin 1 * 1 mL

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56 COMPONENTS MIX 1 * 5 Ampoul

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39 COMPONENTS MIX 1 * 5 Ampoul

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These ambidextrous cleanroom gloves with beaded cuffs can be used in medical as well as in laboratory environments.

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Integrin alpha6 (BQ16) mouse monoclonal IgG1 200 µg/ml raised against UM-UC-9 bladder cancer cell line of human origin 1 * 1 mL

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Human SLC12A3 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human SLC12A3 in tissue homogenates, cell lysates or other biological fluids.

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Human SLC26A4 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human SLC26A4 in serum, plasma, tissue homogenates, cell lysates or other biological fluids.

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Integrin alpha3 (P1B5) mouse monoclonal IgG1 200 µg/ml raised against purified glycoprotein-enriched placenta cells of human orig in 1 * 0,5 mL

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PI 3-kinase p85alpha (B-9) mouse monoclonal IgG1 200 µg/ml raised against amino acids 333-430 mapping within the N-terminus SH2 d omain of the 85 kDa subunit of PI 3-kinase of human origin 1 * 1 mL

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Human KCC2 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human KCC2 in serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

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Human CFTR ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human CFTR in tissue homogenates, cell lysates or other biological fluids.