71223 Results for: "(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl+chloride"

Supplier: Alpha Packaging

FLO-PAK 15CUFT 1 * 1 items

Supplier: Roth Carl

a+ß-Thujone (isomers) 1 * 50 g

Supplier: Chemicon

Rabbit anti-NF-Y A subunit (Hu Ms) polyclonal antibody (Chemicon: AB3012) 1 * 100 µG

Supplier: Roth Carl

a-D(+)-Glucose monohydrate 1 * 50 kg

Supplier: Santa Cruz Biotechnology

IKB-A (1-317) 1 * 10 µG

Supplier: Bioss

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.

Supplier: Bioss

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.

Supplier: Cell Signaling

PATHSCAN® TOTAL Α-SYNUCLEIN SANDWICH ELISA KIT 1 * 1 KIT

Supplier: EPPENDORF

Eppendorf twin.tec® real-time PCR plates, designed for low-volume qPCR, utilise white wells to enhance fluorescent light reflection, improving sensitivity and reproducibility in assays for reliable results.

Supplier: OriGene

TRUECLONE NM_000678.2 1 * 10 µG

Supplier: Alpha Packaging

CLEAR BAG, 381X508MM62.5 MICRON 1 * 500 items

Supplier: Alpha Packaging

BAG PINK OPAQUE X100 610MM X 1 * 100 items

Supplier: Alpha Packaging

X100 SACK FOR DOMESTIC WASTE 1 * 100 items

Supplier: Alpha Packaging

POUCHES 70MU VACUUM PACK 360MMX520MM 1 * 500 items

Supplier: Alpha Packaging

460mmx815mmx940mm 1 colour on 1 side, rolls of 100 on coreless rolls 1 * 100 Roll

Supplier: Santa Cruz Biotechnology

ANTI GFRALPHA-1 (N-18) 1ML 1 * 0,1 mL

Supplier: Alpha Packaging

BAG CLEAR POLYTHENE 300G X50 1 * 50 items

Supplier: Alpha Packaging

CLINICAL WASTE BAG YELLOW (EB0532) 279MM 1 * 500 items

Supplier: Santa Cruz Biotechnology

ERalpha (C-311) X mouse monoclonal IgG2a 200 µg/0.1 ml 1 * 200 µG

Supplier: Santa Cruz Biotechnology

IKKalpha (B-8) FITC FITC conjugated 200 µg/ml 1 * 1 mL

Supplier: Alpha Packaging

CLEAR BAG 900MMX1200MM 100 MICRON 1 * 50 items

Supplier: Alpha Packaging

BAG, POLYTHENE, 9 X 12, 3/4IN WITH 3 (008002592) 1 * 1.000 items

Supplier: Alpha Packaging

SACK X100 275 GAUGE POLYETHYLE 1 * 100 items

Supplier: Alpha Packaging

X100 SACK PRODUCTION 250 GAUGE 1 * 100 items

Supplier: Alpha Packaging

Plain Red Bag - No Label 610 x 990mm 1 * 100 items

Supplier: Alpha Packaging

CLEAR SHAPED CUT POLYTHEBE SHEETS Size: 660X660MM 125MU 1 * 1.000 items

Supplier: Alpha Packaging

BAG, POLY, S/SEAL, WHITE PANEL, 89 X 114MM 1 * 1.000 items

Supplier: Alpha Packaging

457mmx737mmx940mm plain bags supplied in rolls of 25, 4 rolls per case 200 cases 1 * 100 items

Supplier: EPPENDORF

Eppendorf twin.tec® PCR plates LoBind, available in 96 and 384-well formats, maximize nucleic acid recovery and are certified as 'PCR clean' for consistently reliable results.

Supplier: ProSci Inc.

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.