Human Recombinant FLT-3 (CTGrade GMP) (from E. coli)

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About this item

IL-6 is an important pro-inflammatory and anti-inflammatory cytokine expressed by T cells, macrophages, and muscle cells. Signals through a receptor complex containing two receptors, IL-6Rα and gp130. Plays an important function in promoting fever and can serve to stimulate an immune response to trauma.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

IL-6 is often used for growth of hybridoma cell lines. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.

Host cell protein: ≤30 ng/ml
Host cell DNA: ≤0,01 ng/ml
Sterility testing: No growth
Mycoplasma: Negative

Caution: For research use or further manufacturing only.

Specifications

Conjugation:
Unconjugated
Protein function:
Cytokine
Protein/peptide type:
Recombinant
Source:
E. coli
Species:
Human
Storage conditions:
At or below −20 °C
Endotoxin content:
Endotoxin LAL (EU/µg) ≤0.05
Biological activity:
Bioactivity assay: Proliferation of OCI-Aml5, ED50 ≤5 ng/ml, bioactivity ≥1,6×10³ IU/µg
Gene ID:
P49771
Reconstitution instructions:
Sterile water at 0,1 - 0,5 mg/ml
Endotoxin-free:
N
Carrier-free:
Y
Protease-free:
N
Animal-free:
Y
Protein synonyms:
Flt3L|Fms-related tyrosine kinase 3 ligand
Purity:
≥97%
Molecular weight:
17,7 kDa
Sequence:
MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCLE LQCQPDSSTL PPPWSPRPLE ATAPT
Endotoxin level:
Low
Formulation:
10 mM sodium phosphate, 50 mM sodium chloride, pH 7,5
Nuclease-free:
N
Grade:
GMP
Shipping temperature:
Ambient
Tested applications:
Bioassay