IL-21 is a common chain cytokine regulating many cell types of the immune system. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Plays an important role in the development of humoral immunity through its effects on B cell biology including differentiation, affinity maturation, and memory responses.

• High quality
• Low endotoxin
• Lot-to-lot consistency
• Animal free
• Manufactured following GMP guidelines

Regulates T cell responses including survival of CD8+ T cells and inhibition of Treg cells. IL-21 plays a pivotal role in Hodgkin’s lymphoma and suppresses contact hypersensitivity reactions. Promotes a less differentiated phenotype of CAR T cells while promoting the effector functions of the engineered cells. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.

Host cell protein: ≤30 ng/ml
Host cell DNA: ≤0,01 ng/ml
Sterility testing: No growth
Mycoplasma: Negative