Anti-TNF-alpha Mouse Monoclonal Antibody [clone: MT15B15] (PF488P)

STMC100-1462

: STEMCELL Technologies

STMC100-1462

: STEMCELL Technologies

Antigen name:
TNF-alpha
Clonality:
Monoclonal
Clone:
MT15B15
Host:
Mouse
Isotype:
IgG1
Reactivity:
Human
Environmentally Preferable:
Gene ID:
7124
Pk:
100 Tests

Mouse monoclonal antibody against human TNF-alpha, PF488P-conjugated.

Macrophages
T cells

This mouse monoclonal antibody (clone MT15B15) reacts with human tumor necrosis factor alpha (TNF-α). TNF-α is a pro-inflammatory cytokine primarily produced by macrophages and T cells in response to infection and inflammation. Initially generated as a ~26 kDa transmembrane precursor, TNF-α is then processed by metalloproteinases into a ~17 kDa soluble product. Both forms of TNF-α are active in trimeric form and exert their effects via binding to either TNFR1, present on the surface of nearly all human cell types, or TNFR2, which is localized to immune and endothelial cells. First described as having tumor-necrotic action, TNF-α signaling results in an inflammatory response that includes vasodilation and edema formation, adhesion of leukocytes to the epithelium, and blood coagulation. TNF-α also plays a key role in defense against bacterial, viral, and parasitic infections.

: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: TNF-alpha
Clonality: Monoclonal
Clone: MT15B15
Conjugation: PF488P
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human