Specifications
- Antibody type:Primary
- Antigen name:integrin, alpha M (complement component 3 receptor 3 subunit)
- Antigen symbol:ITGAM
- Clonality:Monoclonal
- Clone:M1/70
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Flow cytometry:Yes
- Host:Rat
- Isotype:IgG2b kappa
- Reactivity:Human,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:P11215
- Antigen synonyms:ITGAM
- Storage buffer:Phosphate-buffered aqueous solution, ≤0,09% Sodium azide, may contain carrier protein/stabiliser, ph 7,2.
- Storage temperature:The product should be stored undiluted at 4 °C and should be protected from prolonged exposure to light. Do not freeze.
- Shipping temperature:4 °C
- Purification:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
- Pk:0,1 mg
Specifications
About this item
The M1/70 monoclonal antibody specifically reacts with the 170 kDa alpha M integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
Type: Primary
Antigen: ITGAM
Clonality: Monoclonal
Clone: M1/70
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Human;Mouse