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Anti-SHOC2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-SHOC2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-7934R-A750
Supplier:  Bioss
Anti-SHOC2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-7934R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    SHOC2
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Epitope:
    36-120/582
  • Form:
    Liquid
  • Gene ID:
    8036
  • Antigen synonyms:
    SHOC2_HUMAN|Ras-binding protein Sur-8|Leucine-rich repeat protein SHOC-2|KIAA0862|Protein Sur-8 homolog|SHOC2|Protein soc-2 homolog
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    65 kDa
  • Storage temperature:
    Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human SHOC2/Sur8
  • Tested applications:
    ICC
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialised signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.

Type: Primary
Antigen: SHOC2
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 36-120/582
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat