- Antibody type:Primary
- Antigen name:PGGT1A
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:301-379/379
- Form:Liquid
- Gene ID:2339
- Antigen synonyms:Farnesyltransferase CAAX box alpha|Ras proteins prenyltransferase subunit alpha|Protein prenyltransferase alpha subunit repeat containing 2|Type I protein geranyl geranyltransferase alpha subunit|FPTA|Farnesyl protein transferase alpha subunit|FTase alpha|PGGT1A|Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit|Ras proteins prenyltransferase alpha|PTAR2|Farnesyltransferase, CAAX box, alpha|GGTase I alpha|FNTA_HUMAN|CAAX farnesyltransferase alpha subunit
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human PGGT1A/FNTA
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localisation of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the Signalling pathway which involves p21ras, an important substrate for farnesyltransferase.
Type: Primary
Antigen: PGGT1A
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 301-379/379
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat