Specificaties
- Pk:50 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Human
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Biological activity:This mutant IL-15/Fc fusion protein specifically binds to the IL-15R, competitively inhibits IL-15-triggered cell proliferation, promotes transplant tolerance, does not activate the STAT-signaling pathway, and exerts a prolonged circulating half-life caused by the modified Fc domain.
- Protein synonyms:Interleukin-15
- Protein/peptide name:IL-15 mutant
- Purity:>98% (SDS-PAGE)
- Sequence:49-162
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specificaties
Over dit artikel
Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumour mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumour antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumour-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumour effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumour vaccines.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.