- Pk:50 µG
- Protein/peptide type:Recombinant
- Species:Mouse
- Tag sequence:C-6 His tag
- Storage conditions:Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
- Protein synonyms:Lymphocyte antigen 84|Protein T1|Protein ST2|IL-1 R4|Il1rl1|Fit-1|Ly84|IL-33R|suppression of tumorigenicity 2|ST2V|DER4|Interleukin-1 receptor-like 1|ST2L|IL-1RL1
- Protein/peptide name:ST2
- Purity:> 95% as determined by reducing SDS-PAGE
- Molecular weight:36.6 kD
- Sequence:Ser27-Ala337
- Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor alpha chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.
Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.