- Pk:200 µG
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Biological activity:Measured by its binding ability in a functional ELISA.
Immobilized Mouse PD-L1 / B7-H1 Protein, Fc Tag (Cat# PD1-M5251, 1ug/well) can bind Biotinylated Mouse PD-1 / PDCD1, Fc Tag, Avi Tag (Avitag™) (Cat# PD1-M82F4). The linear range is 0.15-2.5 ug/mL. - Protein synonyms:B7-H1|PD-L1|CD274|PDCD1L1|PDCD1LG1
- Protein/peptide name:PDL16
- Purity:>92% as determined by SDS-PAGE.
- Molecular weight:51.4 kDa
- Formulation:Lyophilized, 50 mM tris, 100 mM glycine, pH7.5
- Tested applications:Western Blot
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.