Specifications
- Pk:20 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is = 0.1 ng/mL, corresponding to a specific activity of = 1 x 107 units/mg.
- Protein synonyms:Granulocyte-macrophage colony-stimulating factor|GMCSF|Colony-stimulating factor|GM-CSF
- Protein/peptide name:GMCSF
- Purity:>98%
- Formulation:Lyophilized
- Tested applications:Western Blot, ELISA
Specifications
About this item
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Recombinant murine GM-CSF (40-617) is a 14.2 kDa globular protein consisting of 124 amino acids residues. Recombinant murine GM-CSF (40-621) is a 14.5 kDa globular protein consisting of 128 amino acids residues.
- Store in working aliquots at -20°C. Avoid freeze/thaw cycles.