Specifications
- Antibody type:Primary
- Antigen name:Adaptor-Related Protein Complex 2, Alpha 2 Subunit
- Antigen symbol:AP2A2
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 350
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:161
- Antigen synonyms:KIAA0899|AP2A2|HYPJ|Adapter-related protein complex 2 alpha-2 subunit|AP-2 complex subunit alpha-2|Alpha2-adaptin|ADTAB|Alpha-adaptin C|HIP9|100 kDa coated vesicle protein C|Adaptor protein complex AP-2 subunit alpha-2|CLAPA2|Clathrin assembly
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:25-75/939
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: AP2A2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat