Recognizes an N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3 (WS: IV & V). Its epitope localizes in the D2 extracellular domain and is resistant to neuraminidase and proteases. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signalling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This MAb inhibits primary mixed lymphocyte culture (MLC) but not secondary MLC, cytotoxicity or proliferation induced by mitogens. It blocks binding of NK1-L16 stimulated T cells to L cells expressing CD50. This MAb is excellent for staining of formalin/paraffin tissues.
Type: Primary
Antigen: ICAM3
Clonality: Monoclonal
Clone: 101-1D2
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human
- Catalog No:
- BNC400177-500
- BNC400177-100
- Antigen symbol:
- ICAM3
- ICAM3
- Antigen name:
- CD50
- CD50
- Antigen synonyms:
- ICAMR|Intercellular adhesion molecule 3 (ICAM3)
- ICAMR|Intercellular adhesion molecule 3 (ICAM3)
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 640R
- CF® 640R
- Clone:
- Clone 101-1D2
- Clone 101-1D2
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 354563
- 354563
- Isotype:
- IgG2a kappa
- IgG2a kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
: VWR Chemicals
: VWR Collection
: VWR Collection
: VWR Chemicals
: KIMBERLY CLARK
: VWR Collection
: VWR Collection
: VWR Collection