The Bcl-2 family of proteins regulate the intrinsic apoptotic pathway and are characterized by the sharing of at least one of four conserved Bcl-2 Homology (BH) domains.

• Dilution Range: 10 µg/ml for Flow Cytometry, 1 µg/ml, ECL for Western blot
• Detects a band of ~26kDa by Western blot

Bcl-2 family members function as either pro- or anti-apoptotic factors, and are generally categorized into three groups based on structural homology and function. Bcl-2-like proteins (Bcl-2, Bcl-xL, Bcl-w, A1, and Mcl-1) are pro-survival. Pro-apoptotic members can be sub-divided into two groups: the multi-BH domain group, including Bax, Bak, and Bok; and the more numerous and diverse BH3-only group, which includes Bim, Bad, and Bid.

Type: Primary
Antigen: B-cell lymphoma 2
Clonality: Monoclonal
Clone: 83-8B
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Drosophila, Human, Mouse, Rat