Anti-CEA is employed essentially as a tool to assist in the distinction between adenocarcinoma and epithelioid malignant mesotheliomas,¹ along with other markers such as those against calretinin, CK 5&6, CD15, HBME-1, MOC-31, and Ber-EP4.¹ Another suggested use of anti-CEA is to immunophenotype various metastatic adenocarcinomas as a means of identifying their origin within a panel of different markers.¹ Its positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.^2,3 Polyclonal anti-CEA is useful in staining hepatocellular carcinoma in a canalicular pattern.^2,4

• Visualization: cytoplasmic
• Control: colon
• Dilution Range: 1:200-1:500

References
1. Shield PW, et al. Am J Clin Pathol. 1996; 105:157-62.
2. Sheahan K, et al. Am J Clin Pathol. 1990; 94:157-64.
3. Alkushi A, et al. Virchows Arch. 2003; 442:271-7.
4. Morrison C, et al. Mod Pathol. 2002; 15:1279-87.

Type: Primary
Antigen: CEACAM5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human