Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (δ F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.

• For Immunocytochemistry, Immunoprecipitation, Western Blot

Recognizes human and mouse CFTR. Detects a band of ~170kDa by Western blot. Cross-reacts with related proteins in mouse cell line Heb7a that doesn not contain CFTR mRNA.

Type: Primary
Antigen: CFTR
Clonality: Monoclonal
Clone: 0
Conjugation:
Epitope:
Host: Mouse
Isotype: IgM
Reactivity: