Anti-ALAS-E Rabbit Polyclonal Antibody (Alexa Fluor® 750)

BOSSBS-9516R-A750

Anti-ALAS-E Rabbit Polyclonal Antibody (Alexa Fluor® 750)

BOSSBS-9516R-A750

Antibody type:
Primary
Antigen name:
ALAS-E
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 750
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Western blot:
Yes
Epitope:
101-200/587
Form:
Liquid
Gene ID:
212
Antigen synonyms:
5-aminolevulinate synthase|5-aminolevulinate synthase 2|5 aminolevulinic acid synthase 2|ALASE|Delta aminolevulinate synthase|ALAS|Delta ALA synthase 2|Aminolevulinate, delta-, synthase 2|ALAS, erythroid|Erythroid specic ALAS|5-aminolevulinic acid synthase|Delta aminolevulinate synthase 2|ASB|Aminolevulinic acid synthase 2, erythroid|Delta ALA synthetase|ALAS E|FLJ93603|XLSA|5-aminolevulinate synthase, erythroid-specic, mitochondrial|Alas 2|XLDPP|ANH1
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Storage temperature:
Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human ALAS2/ALAS-E
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentiation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

Type: Primary
Antigen: ALAS-E
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-200/587
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat