Anti-NFKBIE Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog # BOSSBS-5517R-A488

Supplier: Bioss

Catalog # BOSSBS-5517R-A488

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Epsilon
Antigen symbol:
NFKBIE
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 488
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human
Cross adsorption:
No
Form:
liquid
Gene ID:
4794
Antigen synonyms:
IkB-E|ikB-epsilon|NF-kappa-BIE|I-kappa-B-epsilon|IKBE
Modification:
phospho-Ser157
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at 4°C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Pk:
100 µl

Specifications

About this item

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: IKB epsilon
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human