Anti-KDM5A Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)

Catalog # BOSSBS-16947R-A680

Supplier: Bioss

Catalog # BOSSBS-16947R-A680

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
KDM5A
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 680
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human
Western blot:
Yes
Environmentally Preferable:
Epitope:
101-200/1690
Form:
Liquid
Gene ID:
5927
Antigen synonyms:
RBP2|RBBP2|KDM5A|Retinoblastoma-binding protein 2|Jumonji/ARID domain-containing protein 1A|JARID1A|RBBP-2|Lysine-specific demethylase 5A|Histone demethylase JARID1A
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
192 kDa
Storage temperature:
Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human KDM5A
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Specifications

About this item

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).

Type: Primary
Antigen: KDM5A
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 101-200/1690
Host: Rabbit
Isotype: IgG
Reactivity: Human