Anti-SREBP-1/2 Rabbit Polyclonal Antibody (Cy5®)

BOSSBS-1402R-CY5

Anti-SREBP-1/2 Rabbit Polyclonal Antibody (Cy5®)

BOSSBS-1402R-CY5

Antibody type:
Primary
Antigen name:
SREBP-1/2
Clonality:
Polyclonal
Conjugation:
Cy5®
Host:
Rabbit
ImmunoChemistry:
Yes
ImmunoFluorescence:
Yes
Isotype:
IgG
Reactivity:
Human,
Bovine,
Rat,
Mouse
Western blot:
Yes
Environmentally Preferable:
Epitope:
301-450/1147
Form:
Liquid
Gene ID:
6720, 6721
Antigen synonyms:
SREBF 1|Sterol regulatory element binding protein 1|Sterol regulatory element binding transcription factor 1.|BHLHD1|SREBP 1c|ADD 1|Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1|D630008H06|SREBP1|SREBP 1|SREBF1
Modification:
Unmodified
Storage buffer:
Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
Molecular weight:
54/126 kDa
Storage temperature:
Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Concentration:
1 µg/µl
Shipping temperature:
4 °C
Immunogen:
KLH conjugated synthetic peptide derived from human SREBP-1
Tested applications:
ICC
Purification:
Purified by Protein A
Pack type:
Vial
Pk:
100 µl

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.

Type: Primary
Antigen: SREBP-1/2
Clonality: Polyclonal
Clone:
Conjugation: Cy5
Public Immunogen Range: 301-450/1147
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Bovine