Supplier: ProSci Inc.

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Supplier: ProSci Inc.

PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including poly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate- specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.

Supplier: ProSci Inc.

Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ-B-regulated promoters during inflammatory responses triggered by cytokines.

Supplier: ProSci Inc.

NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Supplier: ProSci Inc.

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Supplier: ProSci Inc.

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Supplier: ProSci Inc.

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Supplier: ProSci Inc.

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: ProSci Inc.

This mAb recognises a protein of 170 kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: Antibodies.com

Human CD74 ELISA kit is a 90 minute sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human CD74 in serum, plasma, and other biological fluids.

Supplier: ProSci Inc.

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Supplier: ProSci Inc.

CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34. It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories.

Supplier: ProSci Inc.

FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

Supplier: Avantor Fluid Handling

Versatile pumps for process applications – with an intuitive touch-screen interface and advanced connectivity.

Supplier: Avantor Fluid Handling

Versatile gear pump drives for high-accuracy, pulseless fluid delivery – with an intuitive touch-screen interface.

Supplier: OHAUS

The Pioneer PX series of semi-micro balances combines essential weighing functionality with performance, offering high accuracy and repeatability for basic applications in laboratory, industrial and education settings. PX models are economically priced, and intuitively designed for intelligent operation. Their durable design has a cast metal lower housing, metal sub-pan and stainless steel weighing pan for long-term use.

Supplier: OHAUS

A range of balances that incorporate a touch screen, advanced weighing and proximity sensor technologies. The easy to use control unit can be mounted on a base, above a base on an optional column, on a wall, or remotely (up to 3 metres distant with an optional cable). The touch screen display, with universal icons and informative prompts, simplifies set-up functions and basic operation. Then the operator has the added choice to use proximity sensors for hands-free operation when handling sensitive samples. These balances have multiple application modes from basic weighing to SQC applications, together with short stabilisation times and optimised performance specifications.

Supplier: Bel-Art Products, a Part of SP

Accurate, repetitive aliquoting into microplate wells is simplified by placing the plate on the adjustable stand and setting the slant to an optimal angle. The slanted plate permits the user to track which wells have received aliquots by visibly contrasting the menisci between adjoining wells.

Supplier: Mettler - Toledo

These portable meters provide high quality pH/mV measurements with the simple click of a button. The robust and waterproof design makes the FiveGo instruments the perfect companion to get reliable measurement data even in harsh conditions. Ideal for mobile applications in the laboratory, at-line, or outdoors.

Supplier: Thermo Fisher Scientific

The Thermo Scientific™ IntelliStack™ Incubator shaker is a versatile laboratory instrument used for incubating and agitating samples simultaneously. It combines the functions of an incubator and shaker, providing a controlled environment for cell culture, microbial growth, and various other applications. With adjustable temperature, speed, and humidity settings, it offers precise control over experimental conditions. A large, easy-to-use 10" colour touchscreen display with real-time monitoring of key parameters and alarms, alerts, and data logging with export via USB or Ethernet allows easy operation, enabling users to set and maintain specific temperature, speed, humidity level, and duration parameters to meet the requirements of various applications.

Supplier: LEICA MICROSYSTEMS

Emspira 3 digital microscope empowers users to streamline inspection processes, cover inspection needs flexibly, and work with confidence. An ideal partner for manipulation, quality control, inspection and research applications.

Supplier: Merck

Milli-Q® IQ Element water purification and dispensing unit is designed to fit into your trace analysis workflow. The Milli-Q® IQ Element unit, combined with a Milli-Q® IQ 7 series water purification system, delivers analytical grade ultrapure water that is suitable for trace and ultra-trace elemental analyses, including ICP-MS, GF-AAS and trace IC.

Supplier: LEICA MICROSYSTEMS

Ivesta 3 – For inspection and rework only, but no camera for documentation is needed.
Ivesta 3 with C-mount – Gives you the flexibility to add a camera if needed and thus turn it into a digital microscope solution.
Ivesta 3 with integrated camera – For digital image sharing directly on different devices, such as, a monitor, mobile device, or computer.

Supplier: LEICA MICROSYSTEMS

Leica (brightfield) colour cameras provide outstanding colour fidelity due to state-of-the-art colour interpolation algorithms performed in the camera head. Leica fluorescence cameras provide high sensor sensitivity allowing short exposure times and, therefore, preventing photo bleaching, so actively protecting cells from any photo damage.

Supplier: Sartorius Balances

Semi-micro balances have a readability of 0,01 mg or 10 µg and a maximum weighing capacity of up to 220 g.

Supplier: OHAUS

A range of four-place balances that incorporate a touch screen, advanced weighing and proximity sensor technologies. The easy to use control unit can be mounted on a base, above a base on an optional column, on a wall, or remotely (up to 3 metres distance with an optional cable). The touch screen display, with universal icons and informative prompts, simplifies set-up functions and basic operation. The operator has the added choice to use proximity sensors for hands-free operation when handling sensitive samples. These balances have multiple application modes from basic weighing to SQC applications, together with short stabilisation times and optimised performance specifications.

Supplier: LTE SCIENTIFIC

‘K’ series models are designed to operate using either a steam generator situated beneath the chamber, or via the customer's own direct steam supply. This arrangement maximises the usable chamber volume and provides a clean, unencumbered chamber, free from heaters and water.