Anti-MSK1/2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Supplier: Bioss

MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain. MSK2 plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.

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Anti-MSK1/2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Supplier: Bioss

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Cooled incubators, HettCube Range

Supplier: Hettich

The HettCube range of cooled incubators provide functionality and customised features. The inner chamber is made from acid-proof stainless steel (DIN 1.4301). Units only heat and cool as necessary, ensuring lower power consumption, operating costs and environmental impact. At an operating temperature of 37 °C the units consume less than 0,05 kWh. The fan is located outside the usable space, so there is a low air flow inside the chamber and a low noise level.

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EXHALATIONVALVE G31 FR HALF-MASK 1 * 10 items

Supplier: BARTELS RIEGER

EXHALATIONVALVE G31 FR HALF-MASK 1 * 10 items

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Cooled incubators, Series 1A

Supplier: LMS

LMS Series 1A cooled incubators are temperature controlled cabinets with fan assisted air circulation via a pre-mixing chamber. The units have a white enamelled sheet steel exterior, white pre-coated aluminium interior and polyurethane foam insulation, and feature a door lock and magnetic door gasket. The inner chamber is easy to clean, disinfection procedures are detailed in the user manual.

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LOWER RACK 12 PL. - 50ML COLL. TUBES 1 * 1 items

Supplier: VARIAN

LOWER RACK 12 PL. - 50ML COLL. TUBES 1 * 1 items

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Phalloidin conjugates

Supplier: Biotium

Phalloidin is a toxin isolated from the deadly Amanita phalloides mushroom. It is a bicyclic peptide that binds specifically to F-actin. Fluorescent conjugates of phalloidin are convenient tools to investigate the distribution of F-actin in fixed and permeabilised cells or tissue sections. One unit (U) of phallodin is sufficient to stain one sample (200 µl staining volume). A highly selective actin filament stain for fixed and permeabilised cells. Labeled phalloidins have similar affinity for both large and small filaments.

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CONNECTOR BOARD 31POLE FLANGE PRI 1 * 1 items

Supplier: LAUDA

CONNECTOR BOARD 31POLE FLANGE PRI 1 * 1 items

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VWR® INCU-Line® ILCO 180 and ILCO260 Premium, CO₂ Incubators

Supplier: VWR Collection

The ILCO 180 and ILCO 260 Premium offer optimal growth conditions for cell cultures and meet demanding requirements for best possible cell growth and maximum sample safety. These CO₂ incubators come with a built-in, drift-free infrared CO₂ sensor that can be sterilised. Reliable decontamination is provided by the standard-compliant 180 °C hot air sterilisation routine which completely eliminates contaminants and ensures the inner chamber is completely sterilised. They have an intuitive menu and user friendly software, also USB port for data download to USB stick and for uploading programs. They can be connected to Ethernet or Wi-Fi networks for remote control from any computer, and users can receive notifications about alarms/events via e-mail.