11693 Results for: "Tissue+Embedders&pageNo=21&view=list"
Ultra low temperature freezers, with 4 inner doors, –86 °C, TDE series
Supplier: Thermo Scientific
Thermo Scientific™ TDE Series ultra-low temperature freezers, powered by H-drive, feature four upright models, maximizing storage capacity from 30000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every laboratory. Sustainability features include natural refrigerants and water-blown foam, compliant with many sustainability standards.
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Anti-BRCA2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Supplier: Bioss
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localisation at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).
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Anti-TRIM21 Rabbit Polyclonal Antibody (Cy5®)
Supplier: Bioss
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
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Discover our special offers on laboratory products from Consumables to Equipment used in every lab!
SPE sorbents, CHROMABOND®
Supplier: MACHEREY-NAGEL
The high purity CHROMABOND® adsorbents can be used for a self-filling of SPE columns or further analytical applications.
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Semi-micro balances, Cubis® II series
Supplier: Sartorius Balances
The Cubis® II range has a modular design that to allows the customer to choose the components that suit the application area that is of interest. For the customer, this configurable concept delivers quality weighing, together with a high degree of flexibility, without having to invest in expensive equipment that has features that may never be required.
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Gastight® 1000 series syringes
Supplier: HAMILTON BONADUZ
The 1000 series is a mid volume Gastight® syringe. Gastight® syringes are ideal for dispensing both liquids and gases. They have a precision machined PTFE plunger tip which creates a leak-free seal. With the tight fit, the tip essentially wipes the interior of the syringe barrel free of sample. This feature is particularly useful with heterogeneous samples as it reduces the chance that a deposit will occur and cause the plunger to freeze.
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Rotary evaporators, Hei-VAP Core
Supplier: Heidolph Instruments GmbH & Co.KG
These evaporators are equipped with proven smart details such as Easy-Clip, patented clamping sleeve, lift stop to limit immersion depth and universal 5 L heating bath.
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Anti-TRIM21 Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
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Anti-TRIM21 Rabbit Polyclonal Antibody (Cy3®)
Supplier: Bioss
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
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Gastight® 1700 series syringes
Supplier: HAMILTON BONADUZ
These syringes are the Gastight® version of the original 700 series syringes and are ideal for dispensing volumes from 1 µl up to 500 µl.
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Ultrapure water systems, arium® pro
Supplier: Sartorius
Arium® pro Type I water purification systems are designed for sophisticated users to meet all their requirements for reagent grade water, needed both for critical applications and routine analyses. Different versions are available for reliable and optimal analytical results.
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HDPE BOTTLE PACKAGING BOTTLE 1000ML 1 * 10 items
Supplier: SEMADENI
HDPE BOTTLE PACKAGING BOTTLE 1000ML 1 * 10 items
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CRYOPLUS PCB MINI T B/PASS PRO KT 1 * 1 items
Supplier: Thermo Fisher Scientific
CRYOPLUS PCB MINI T B/PASS PRO KT 1 * 1 items
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Flask volumetric pyrex, class A, 50 ml, ukas certified 1 * 1 items
Supplier: SciLabware
Flask volumetric pyrex, class A, 50 ml, ukas certified 1 * 1 items
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VWR® LED and LCD Ultrasonic Cleaning Baths
Supplier: VWR Collection
The housing and tank are constructed from high-quality SUS 304 stainless steel, providing durability and longevity. Equipped with user-friendly interface display which offers intuitive function selection and real-time parameter setting. Units also feature intelligent detection on startup, promptly alerting users to any potential issues via buzzer and alarm. Additionally, they continuously monitor the power supply voltage in real-time to ensure optimal operating conditions. The automatic heating stirring function ensures uniform liquid temperature throughout the tank. The anti-leakage tray prevents damage to electrical components and avoids the risk of hazard in case of leakage.
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Cleanroom tables, BLAUTOUCH
Supplier: LABORIAL
Innovative interactive worktop for laboratories, cleanrooms and healthcare. A hygienic design based on GMP guidlines which consists of a continuous, tempered glass surface on phenolic resin laminate in which is embedded a touch control screen, to provide an interactive worktop, all supported on a metallic structure. At the same time, it works as a regular worktop and solves the disinfection and contamination problems associated with the use of tablets, notebooks, PCs, keyboards and mouse in cleanrooms and other controlled environments. It allows access to any laboratory software such as electronic notebooks, LIMS, Wikis, analysis software, Office and others, on the laboratory workbench, whilst maintaining an aseptic environment. The interactive worktop can help to reduce traffic, in and out of critical areas in which the use of handheld computer devices are restricted or prohibited.
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ACQUITY PREMIER HSS T3 COLUMN WITH 1 * 1 items
Supplier: WATERS
ACQUITY PREMIER HSS T3 COLUMN WITH 1 * 1 items
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HPLC columns, Purospher® STAR RP-18 endcapped
Supplier: Merck
Fast method development of complex samples across the pH range from 1,5 to 10,5 with different mobile phases and temperature conditions.
Purospher® STAR RP-18 endcapped HPLC columns are designed for universal use. Basic, neutral and metal-chelating compounds can easily be separated with simple mobile phases – naturally without peak tailing. Thanks to its outstanding performance and stability, Purospher® STAR RP-18 endcapped offers maximum flexibility in method development. Robust methods can be developed over the entire pH range from 1,5 to 10,5. High pH-stability allows the separation of strongly basic compounds with alkaline eluents. The combination of high purity silica, best all-round retention characteristics, outstanding pH stability up to pH 10,5, and suitability for up to 100% aqueous mobile phases, make Purospher® STAR RP-18 endcapped an all-round top performance column, almost universal in its range of applications.
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HPLC columns, Chromolith®
Supplier: Merck
Monolithic silica technology: A new age in chromatography. Chromolith® columns are based on silica so existing methods can be easily transferred with only minimal investment in new method development work. 'Sol-Gel' technology allows highly porous monolithic rods of silica to be formed. These feature a bimodal pore structure provides a unique combination of macropores and mesopores.
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Test sieve with wooden frame 500x500x80mm - 56mm 1 * 1 items
Supplier: NEXOPART
Test sieve with wooden frame 500x500x80mm - 56mm 1 * 1 items
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Flask volumetric pyrex, class A, amber coloured, 50 ml, ukas certified 1 * 1 items
Supplier: SciLabware
Flask volumetric pyrex, class A, amber coloured, 50 ml, ukas certified 1 * 1 items
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COLUMN ACQUITY PREMIER GLYCAN BEH AMIDE 1 * 1 items
Supplier: WATERS
COLUMN ACQUITY PREMIER GLYCAN BEH AMIDE 1 * 1 items
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Acquity UPLC BEH Shield RP18 1.7um 2.1x30mm Column 1 * 1 items
Supplier: WATERS
Acquity UPLC BEH Shield RP18 1.7um 2.1x30mm Column 1 * 1 items
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CORTECS UPLC C18 Column, 90Å, 1.6µm, 2.1mm X 150mm 1 * 1 items
Supplier: WATERS
CORTECS UPLC C18 Column, 90Å, 1.6µm, 2.1mm X 150mm 1 * 1 items
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Ultra-Low Temperature Freezers, TSX Universal
Supplier: Thermo Scientific
TSX Universal Series ULT Freezers are the pinnacle of reliability, sustainability, and innovation incorporating insights from over 80 years of experience to enhance every aspect of the system. Updates to the variable speed compressors has made the TSX Universal adaptable across all workflows. Available in four capacities, they are ENERGY STAR® certified with a 33% energy efficiency improvement, ACT labeled and produced in a Zero-Waste to Landfill certified facility.
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BATH ULTRASONIC BANDELIN DT 514 H UK 1 * 1 items
Supplier: BANDELIN-ELECTRONIC
BATH ULTRASONIC BANDELIN DT 514 H UK 1 * 1 items
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Stainless-Steel Test Sieves, 450mm Greater than 10mm with ISO 3310/1 1 * 1 items
Supplier: Retsch GmbH
Stainless-Steel Test Sieves, 450mm Greater than 10mm with ISO 3310/1 1 * 1 items
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Analysing Sieve 500X500X80mm, 22.4mm Mw. With Beech Wood Framestainless Steel Wire Acc.To Din En 10 204 1 * 1 items
Supplier: NEXOPART
Analysing Sieve 500X500X80mm, 22.4mm Mw. With Beech Wood Framestainless Steel Wire Acc.To Din En 10 204 1 * 1 items
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Anti-TRIM21 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Bioss
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
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Volumetric flask, PMP, class A, with stopper NS 10/19, PP, 25 mL 1 * 2 items
Supplier: VITLAB
Volumetric flask, PMP, class A, with stopper NS 10/19, PP, 25 mL 1 * 2 items