5058 Results for: "Taurodeoxycholic+acid+sodium+salt&pageNo=65"

Supplier: Bioss

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Supplier: LABCONCO

Purifier Vertical Clean Benches direct HEPA-filtered air downward over the work area to provide ISO Class 5 (formerly Class 100) conditions and protect your work from particulate contamination. Applications for clean benches include plant tissue culture, media plate preparation, electronics inspection, medical device assembly and pharmacy drug preparation.

Supplier: Bioss

Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognises the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognises and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Supplier: Bioss

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.

Supplier: Bioss

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.

Supplier: Brady

A variety of polyester and specialty materials for thermal transfer printing in wide format rolls designed for shape cutting multiple labels out of a single continuous roll.

Supplier: MACHEREY-NAGEL

NUCLEODUR® C18 HTec is a high density monomeric octadecyl modified silica phase for analytical and preparative HPLC.

Supplier: MP Biomedicals

Cesium chloride, an inorganic compound, is an important source of cesium ions in a variety of applications. Its crystal structure forms a major structural type where each cesium ion is coordinated by 8 chlorine ions. Cesium chloride occurs naturally in mineral waters and as an impurity in carnallite (up to 0.002%), sylvite and kainite. Less than 20 tonnes of CsCl is produced annually worldwide, mostly from a cesium-bearing mineral pollucite.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce EMCS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).

Supplier: Brady

Rugged, durable, and reliable, the Magicard 300 printers are perfect for schools, universities, and mid-sized businesses that print more than 10000 cards per year. You can trust the Magicard™ 300 printers for secure and reliable ID card printing.

Supplier: Bioss

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.

Supplier: Bioss

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.

Supplier: Bioss

The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. Development of the vertebrate gut is controlled by paracrine crosstalk between the endodermal epithelium and the associated splanchnic mesoderm. FOXF2 (forkhead box F2), also known as FKHL or FREAC2, is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. FOXF2 interacts with transcription factors TFIIB and TBP, and may be involved in regulating transcription in embryogenesis and pattern formation in multicellular organisms. FOXF2-deficient mice develop cleft palate and an abnormal tongue, which suggests that FOXF2 may be critical for palatogenesis.

Supplier: Testo

Official temperature control measurements are carried out with this set for food inspectors, appraisers and authorities. Consists of the conformity-assessed testo 112 temperature measuring instrument in TopSafe protective case and the conformity-assessed Pt100 food probe safely stowed away in the transport bag.

Supplier: MACHEREY-NAGEL

NUCLEODUR® C8 Gravity is an octyl modified silica phase with a high density coverage, using for HPLC.

Supplier: MACHEREY-NAGEL

NUCLEODUR® C18 Pyramid is an octadecyl modified silica phase with polar endcapping, especially designed for use in eluent systems of up to 100% water.

Supplier: Cytiva

2-D Quant Kit is designed for the accurate determination of protein concentration in samples prepared for electrophoresis techniques such as 2-D electrophoresis, SDS-PAGE, or IEF.

Supplier: NEW PIG

Extra perforations let you create custom sizes of PIG Mat without cutting. Just "rip" it along the easy-tear perfs and "fit" it into place.

Supplier: Thermo Fisher Scientific

Thermo Scientific Pierce LC-SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long cyclohexane-stabilized spacer arm (16.2 angstroms).

Supplier: NEW PIG

Booms made from PP skin (UV resistant up to 12 months), PP filler and a tough outer mesh which is UV resistant for long-term outdoor use without degradation. The PP filler is chemical-resistant and hydrophobic for containing and absorbing oil-based spills. The booms float at water surface for easy retrieval, even when saturated.

Supplier: COMARK

The BT125 is designed for use in the kitchen and other food production areas. The Bluetooth Pocketherm thermometer transmits temperature data via Bluetooth to your Android or iOS phone or tablet.

Supplier: tempmate

Pre-programmed. Intuitive multi-use temperature logger for reliable low-cost cold chain monitoring. For temperature and humidity recording with internal or external temperature and humidity sensor, multifunction display and automatic PDF report generation.

Supplier: MP Biomedicals

Carboxymethyl Cellulose Sodium Salt is a high viscosity carboxymethylcellulose (CMC); the viscosity of a 1% solution in water at 25 °C is 1300-2200 centipoise (cps). The viscosity is both concentration and temperature dependent. As the temperaure increases, the viscosity decreases. As the concentration increases, the viscosity increases.

Supplier: Bioss

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type II beta(sodium channel, voltage-gated, type II, beta), also known as SCN2B, is a 215 amino acid single-pass type I membrane protein that plays a critical role in the expression and assembly of the heterotrimeric complex of the sodium channel and interacts with Tenascin-R to influence the clustering and regulation of sodium channels at nodes of Ranvier. Expressed specifically in brain, Na+ CP type II beta contains one Ig-like C2-type (immunoglobulin-like) domain and is encoded by a gene that maps to human chromosome 11q23.3 and mouse chromosome 9 A5.2.

Supplier: Merck

Dehydrated media are used for a wide variety of applications. To minimise the risks associated with powdered culture media, the majority of Merck's dehydrated culture media is produced in granular form. Merck uses ingredients of non animal origin to minimise the potential risk of transmissible spongiform encephalitis (TSE). When there is no alternative, only ingredients which are recommended by EDQM, and belonging to TSE category B or C are used. This ensures that the product is of the highest quality and in compliance with the standards for food control, microbiological testing on finished products and starting materials, and quality control in the pharmaceuticals and cosmetics industries. Custom-made media can be prepared to meet individual customer specifications. The formulation is kept confidential via a Non Disclosure Agreement. Please enquire for further details. Advantages of granulated Merck media.

Supplier: Thermo Fisher Scientific

Protein desalting spin columns are designed to desalt or exchange buffer of protein samples with volumes of 30 to 120 µl. These devices have exceptional desalting characteristics with ≥95% retention of salts and small molecules while providing excellent recovery of proteins greater than 7 kDa. Multiple samples can be processed in less than five minutes without cumbersome column preparation steps.

Supplier: Portwest

Breathable jacket made of 300 Denier polyester yarn which features superior abrasion and tear resistance.

Supplier: Thermo Fisher Scientific

The glycoprotein isolation kit allows isolation of glycoproteins from complex mixtures, including serum, tissue and cultured cell lysates. The procedure uses concanavilin A (ConA) or wheat germ agglutinin (WGA) as a ligand to bind a specific class of glycoprotein from complex protein samples - those containing alpha-lined mannose or terminal glucose residues (in case of ConA) and N-Acetyl glucosamine (GlcNAc) groups or sialic acid (in case of WGA). This kit has been used to isolate glycoproteins from serum as well as HeLa and CHO cell lysates in approximately 50 minutes.

Supplier: DWK Life Sciences

The Wheaton® R2P™ 2.0 roller culture apparatus is designed to allow for the development and growth of cultured cells from research to production quantities without having to change equipment and revalidate protocols. The R2P™ 2.0 system utilises computerised measurement of the actual bottle speed and allows networking for up to 255 units. Applications include, Viruses for vaccines or related studies, proteins, enzymes, antibodies, live cell assays.

Supplier: LABCONCO

Filtered PCR Enclosures direct HEPA-filtered air downward over the work area to provide ISO Class 5 conditions and protect your work from particulate contamination. These specialized vertical clean benches provide a controlled environment in which to perform polymerase chain reaction experiments. These enclosures include a variable digital timer and when the set time expires, the UV light automatically switches off in preparation for the next experiment.