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Supplier: USP

USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.

Supplier: Bioss

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

Supplier: Bioss

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

Supplier: Thermo Fisher Scientific

Zinc oxide ≥99.9% (metals basis), sputtering target, Ø 50.8 mm (2.0 in), Thickness: 6.35 mm (0.250 in)

Supplier: THERMO NATIONAL SCIENTIFIC

These convenience vial kits contain caps with pre-inserted septa that are not attached to vials.

Supplier: GRANT INSTRUMENTS

The compact PS-3D variable speed, fixed angle 3D rotator is ideally suited for personal use. Applications include mixing in tubes, culture flasks, gel staining, destaining, antibody staining, washes, hybridisations, and blots. The reliable motor produces regulated and reproducible rotating throughout the speed range.

Supplier: Resonac

SEC columns for MALS detctors with ultra-low bleeding.

Supplier: Thermo Fisher Scientific

(S)-2-Amino-4-methoxy-4-oxobutanoic acid hydrochloride 97%

Supplier: MP Biomedicals

Spermine is a naturally occuring polyamine that occurs in all eukaryotes, but is rare in prokaryotes. It is essential for cell growth in both normal and neoplastic tissue.

Supplier: Abcam

Orally active anti-inflammatory, antifibrotic and antiproliferative agent. Blood-brain barrier permeable. Shown to modulate cytokines TGF-β and TNF-α.

Supplier: EUTECH

General purpose "3-in-1" pH/temperature combination electrode for use with CyberScan models (pH 10 / pH 100 / pH 200 / pH 500 / pH 1000 / pH 2000).

Supplier: Corning

This antimycotic interferes with fungal membrane permeability by forming channels in cell membranes, causing small molecules to leak from the cell. It is recommended for use in cell culture applications at 10 ml/L and is stable at 37 ºC for 3 days.

Supplier: Molekula

Urea

Supplier: GA

These labels are available in a range of sizes and configurations, perfect for identifying small diameter cryo vials, microtubes, cardboard or polypropylene cryo/freezer boxes, cell culture plates, and plastic bags.

Supplier: Bioss

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

Supplier: Abcam

Selective MRP1 and P-glycoprotein inhibitor. Chemosensitising agent. Increases the sensitivity of MRP1-overexpressing tumor cells to doxorubicin , vincristine and etoposide. Shows chemosensitising, antitumor effects in vivo.