54791 Results for: "Sodium+tetrakis[3,5-bis(trifluoromethyl)phenyl]borate"

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: Portwest

STEELITE MONSAL SAFETY BOOTS S3 FT05 1 * 1 PAIR

Supplier: Simport Scientific

TUBE 2ML INTERNAL THREAD ROUND BOTTOM 1 * 1.000 items

Supplier: EBRO

TPN 320, K-Type surface probe up to 300°C, Ø 12mm, L 30mm, angled, 1m silicone fixed 1 * 1 items

Supplier: MEMMERT

Stainless steel slide-in drip tray, 15 mm rim (may affect the temperature distribution) - cannot be used in connection with option K 1 1 * 1 items

Supplier: VITLAB

Volumetric flask, PMP, class A, with stopper NS 14/23, PP, 100 mL 1 * 2 items

Supplier: MEMMERT

Additional reinforced stainless steel grid, max. loading 60 kg with guide bars and fixing screws (only in connection with option K1 ) 1 * 1 items

Supplier: ProSci Inc.

Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-421', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

Supplier: ProSci Inc.

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, the microtubule-associated protein MAPT, RHOH or TYROBP.

Supplier: ProSci Inc.

Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and Blys (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc.. Recently, two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI. Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses.

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items

Supplier: MEMMERT

Integration of additional units (up to max. 15 units) into an already existant FDA-software licence 1 * 1 items