15877 Results for: "Sodium+peroxide"

Supplier: MP Biomedicals

Potency:~900 µ g/mg Crystalline Topoisomerase II inhibitor 1 * 1 g

Supplier: MP Biomedicals

Crystalline Purity: 99.5% 1 * 3 kg

Supplier: ProSci Inc.

Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-κ-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652', leading to activate the NF-κ-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters, a class of tumor promoters.

Supplier: ProSci Inc.

SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein.

Supplier: MP Biomedicals

Cell Culture Reagent Anhydrous 1 * 500 g

Supplier: ProSci Inc.

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila).Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN)
functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.

Supplier: ProSci Inc.

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.

Supplier: MP Biomedicals

Potency:~900 µ g/mg Crystalline Topoisomerase II inhibitor 1 * 5 g

Supplier: MP Biomedicals

USP GRADE. 1 * 100 g

Supplier: MP Biomedicals

USP GRADE. 1 * 500 g

Supplier: MP Biomedicals

Cell Culture Reagent Anhydrous 1 * 1 kg

Supplier: MP Biomedicals

Photoinitiator of polymerization useful in either acid or alkaline buffer systems. 1 * 5 g

Supplier: MP Biomedicals

Purity: >98% 1 * 1 kg

Supplier: G-Biosciences

L-lactate is produced from pyruvate by the enzyme Lacate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. S 1 * 50 g

Supplier: G-Biosciences

L-lactate is produced from pyruvate by the enzyme Lacate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. S 1 * 5 g

Supplier: G-Biosciences

molecular grade, concentrated running buffer for dna and rna electrophoresis. 1 * 250 mL

Supplier: ProSci Inc.

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-κB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition, progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

Supplier: ProSci Inc.

Chek1 is a protein kinase that inhibits mitotic entry after DNA damage, required for the DNA damage checkpoint and is strongly similar to murine Chek1. Checkpoint pathways control the order and timing of cell cycle transitions and ensure that critical events, such as DNA replication and chromosome segregation, are completed with high fidelity. The mouse and human proteins share 90% sequence identity through the protein kinase domains. The sequence of the 476-amino acid human Chek1 protein is 29%, 40%, and 44% identical to those of the fission yeast Chek1, C. elegans Chek1, and Drosophila 'grapes' (Grp) proteins, respectively. Chek1 is expressed ubiquitously as an approximately 2.4-kb mRNA, with the most abundant expression in thymus, testis, small intestine, and colon. The protein has altered mobility when isolated from cells treated with ionizing radiation, indicating that Chek1 is modified in response to DNA damage. In vitro, Chek1 directly phosphorylates a regulator of CDC2 tyrosine phosphorylation, CDC25C. In response to DNA damage, Chek1 phosphorylates and inhibits CDC25C, thus preventing activation of the CDC2-Cyclin-B complex and mitotic entry

Supplier: ProSci Inc.

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years. These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

Supplier: ProSci Inc.

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Supplier: G-Biosciences

L-lactate is produced from pyruvate by the enzyme Lacate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. S 1 * 10 g

Supplier: LGC Standards PROMOCHEM

5-(Difluoromethoxy)-2-[[(3 ,4-dimethoxypyridin-2-yl)methyl]sulphanyl]-1H-benzimidazole 1 * 100 mg

Supplier: Cayman Chemical

Cefazolin is a broad-spectrum, first-generation cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram -negative bacteria.{25759} It inhibits bacterial cell wall synthesis, causing growth to cease without lysis (5 µg/ml 1 * 1 g

Supplier: G-Biosciences

Mode of action and Anti-microbial spectrum: Ampicillin is an inhibitor of bacterial cell wall synthesis which acts by inhibiting the cross-linking of peptidoglycan. It is used in the selection of antibiotic cell hybrids, and has a high rate of actio 1 * 10 g

Supplier: G-Biosciences

Mode of action and Anti-microbial spectrum: Ampicillin is an inhibitor of bacterial cell wall synthesis which acts by inhibiting the cross-linking of peptidoglycan. It is used in the selection of antibiotic cell hybrids, and has a high rate of actio 1 * 500 g/mol

Supplier: Cayman Chemical

Cefazolin is a broad-spectrum, first-generation cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram -negative bacteria.{25759} It inhibits bacterial cell wall synthesis, causing growth to cease without lysis (5 µg/ml 1 * 100 mg

Supplier: G-Biosciences

Carbonyl groups, including aldehydes, ketones and glyoxals, react with amines to form Schiff base intermediates that are in equilibr ium with their free forms. The labile Schiff’s base interaction can be stabilized by chemical reduction. 1 * 2.000 mg

Supplier: Cayman Chemical

Cefazolin is a broad-spectrum, first-generation cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram -negative bacteria.{25759} It inhibits bacterial cell wall synthesis, causing growth to cease without lysis (5 µg/ml 1 * 250 mg

Supplier: Cayman Chemical

Cefazolin is a broad-spectrum, first-generation cephalosporin antibiotic that is active in vitro against most Gram-positive and Gram -negative bacteria.{25759} It inhibits bacterial cell wall synthesis, causing growth to cease without lysis (5 µg/ml 1 * 500 mg

Supplier: MP Biomedicals

Purity: >98% 1 * 100 g