5371 Results for: "Primers+and+Probes&pageNo=56"

Supplier: Bioss

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).

Supplier: MIELE

The PLW 8616 laboratory washer can accommodate 216 laboratory flasks, 588 vials, or 294 pipettes. The large glassware washer is flexible and simple to use, it has modular load carriers and SimpleLoad system. This efficient unit has a double door, 900 mm wide, a usable capacity of 351 litres. PLW 8616 provides reliable results, high pump performance with a variable-speed pump and features spray arm monitoring and a conductivity meter.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: THERMO H + P LABORTECHNIK

Sterilfilterkerze Typ Mini 1 * 1 items

Supplier: NEUBERT VOLUME GLASSWAERE

CENTR TUBE200ML 56X145MM GL45 W/O SC/CAP 1 * 1 items

Supplier: DWK Life Sciences

BOAT WEIGHING 6ML GLASS 1 * 1 items

Supplier: ProSci Inc.

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.

Supplier: U-Power

BUNDTROUSERS FLASH PE116AG ASPHALTGRAY56 1 * 1 items

Supplier: GERHARDT

CROSS FLOW FAN FOR STL56 1 * 1 items

Supplier: SEMADENI

PACKING CAN 90 ML PP 1 * 100 items

Supplier: BELIMED

UNIT DIRECT INJECTION,1-LEVEL FOR WD 230 1 * 1 items

Supplier: MARKET SOURCE PART PROCESS

Calibration Set M-560/M-565 1 * 1 items

Supplier: Heidolph Instruments GmbH & Co.KG

Hei-VAP Expert Control rotary evaporators allow central control of all process parameters: Vacuum, cooling temperature, rotation and heating bath temperature. The units have separate knobs for quick access: Right for direct vacuum control, the left one for rotation has a lock function to prevent accidental adjustment

Supplier: NEXOPART

Test sieve with wooden frame 500x500x80mm - 56mm 1 * 1 items

Supplier: UVEX

LABCOAT MEN 473/WHITE MG SIZE XL 1 * 1 items

Supplier: FRITSCH

Test Sieve 200/50 mm, mesh = 0.056 mm ISO 3310-1 1 * 1 items

Supplier: witeg Labortechnik

Tubing threaded 56x130x3.5mm gl60 with screw threaded, straight,acc. to din 12216, with iso screw thread,made of borosilicate glass , available with screw thread gl, rd or svl null

Supplier: BANDELIN-ELECTRONIC

BATH UNTRASONIC BANDELIN DT106 UK 1 * 1 items

Supplier: CUSTOM MADE CHEMICALS LAB

[FR] 8 COMPOSES 100MG/L CHAQUE DANS HNO3 2% 1 * 125 mL

Supplier: witeg Labortechnik

Tubing threaded 56x130x2.5mm gl60 with screw threaded, straight,acc. to din 12216, with iso screw thread,made of borosilicate glass , available with screw thread gl, rd or svl null

Supplier: Binder

Water supply set - external, consisting of fresh- and waste-water containers (20 liters each), cabling and pump 1 * 1 items

Supplier: DEUTSCH NEUMANN

Stopper, silicon, transparent diameter(bottomx top)56x 65x 45mm. 1 * 1 items

Supplier: witeg Labortechnik

Bottle wide mouth, HDPE, content 1000 ML, diameter 100 MM, height 183 MM, mouth inner diameter 50 MM, GL 45, PLOMBIER CAPABLE WITH RED SCREW CAP AND SEAL 1 * 1 items

Supplier: MARKET SOURCE PART PROCESS

TEST INK BLUE OPTIONAL SET 18 mN/m (colourless) and from 20 to 72 mN/m (blue) 1 * 1 KIT

Supplier: CUSTOM MADE CHEMICALS LAB

COMPONENTS MIX 5 1 * 5 Ampoul

Supplier: CUSTOM MADE CHEMICALS LAB

COMPONENT 4 MIX 1 * 10 mL

Supplier: LGC Standards PROMOCHEM

(11RS)-8-CHLORO-11-HYDROXY-11-(1-METHYLP 1 * 100 mg

Supplier: DEUTSCH NEUMANN

Stopper, rubber, grey, diameter(bottomx top)56X65mm, height 45mm1 drilling diameter. 9mm. 1 * 1 items

Supplier: DEUTSCH NEUMANN

Stopper, rubber, grey, diameter(bottomx top)56X65mm, height 45mm1 drilling diameter 21mm. 1 * 1 items

Supplier: DEUTSCH NEUMANN

Stopper, rubber, grey, diameter(bottomx top)56X65mm, height 45mm1 drilling diameter 14mm. 1 * 1 items