48170 Results for: "Phenyl+trifluoromethanesulphonate&pageNo=8"

Supplier: Enzo Life Sciences

Topoisomerase inhibitor

Supplier: Enzo Life Sciences

PXR activator

Supplier: Enzo Life Sciences

LXR ligand.

Supplier: Enzo Life Sciences

Estrogen receptor ligand.

Supplier: Enzo Life Sciences

Estrogen receptor β activator.

Supplier: Enzo Life Sciences

Serotonin receptor ligand.

Supplier: Enzo Life Sciences

Endogenous agonist at melatonin MT1 and MT2 receptors. Displays antioxidant and antiapoptotic effects in numerous cell types as well as beneficial effects in various neurodegenerative diseases. It protects neuronal cells from amyloid beta-mediated oxidative damage and increases survival in an Alzheimer’s disease transgenic mouse model. Melatonin directly inhibits mitochondrial permeability transition pore (IC50 = 0.8M) and reduced the loss of neurons in a rat model of transient brain ischemia.

Supplier: Enzo Life Sciences

K⁺ channel activator.

Supplier: Enzo Life Sciences

Metabolite of alprazolam.

Supplier: Enzo Life Sciences

Na+ channel blocker

Supplier: Enzo Life Sciences

Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM).

Supplier: Enzo Life Sciences

Selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50=0.6µM).

Supplier: Enzo Life Sciences

A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).

Supplier: Enzo Life Sciences

Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.

Supplier: Enzo Life Sciences

Lipoxygenase inhibitor

Supplier: Enzo Life Sciences

Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.

Supplier: Enzo Life Sciences

Cytochrome P450 substrate

Supplier: Enzo Life Sciences

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Supplier: Enzo Life Sciences

Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.

Supplier: Enzo Life Sciences

HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

Supplier: Enzo Life Sciences

General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).

Supplier: Enzo Life Sciences

PKA activator.

Supplier: Enzo Life Sciences

Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

Supplier: Enzo Life Sciences

Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.

Supplier: Enzo Life Sciences

A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.

Supplier: Enzo Life Sciences

GPR119 activator.

Supplier: Enzo Life Sciences

PPAR ligand

Supplier: Enzo Life Sciences

Blocks lipid peroxidation

Supplier: Enzo Life Sciences

FAAH inhibitor

Supplier: Enzo Life Sciences

A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.