48170 Results for: "N-Ethyl-4-aminobenzylamine&pageNo=8"

Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.

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Fingolimod hydrochloride ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A2 independently of sphingosine 1-phosphate receptors.

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BML-284 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Wnt activator

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QS11 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Wnt pathway activator

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Histone Deacetylase Inhibitor VIII ≥98% (by TLC)

Supplier: Enzo Life Sciences

HDAC6 inhibitor

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5(S)-Hydroxyeicosa-6E,8Z,11Z,14Z-tetraenoic acid (HETE) ≥98%

Supplier: Enzo Life Sciences

Biosynthesis via 5-lipoxygenase. Chemotactic and chemokinetic for PMNL. Induces degranulation and calcium flux.

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Cp 31398 Dihydrochloride (synthetic) ≥98% (by TLC)

Supplier: Enzo Life Sciences

CP-31398 restores mutant p53 tumor suppressor function in vitro without affecting p53 homologs p63 and p73, and in vivo inhibiting UVB-induced skin carcinogenesis in mice. Stabilization of p53 inhibits ubiquitination without altering phosphorylation at Ser12 or Ser20 or MDM2 binding. Administration of this or similar compounds has the potential to enhance cytotoxic chemotherapy.

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Actinomycin D (from Streptomyces parvulus) ≥98% (by TLC)

Supplier: Enzo Life Sciences

An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10 µg/mL in cell culture for halting transcription. The product is not sterile.

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DIF-1 ≥98% (by HPLC), Ultrapure

Supplier: Enzo Life Sciences

Induces cell differentiation.

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Z-Guggulsterone ≥98%

Supplier: Enzo Life Sciences

A guggul tree steroid well known for its lipid lowering properties. Acts as a selective antagonist at farnesoid X receptors (FXRs). Inhibits FXR transactivation (IC50=10µM).

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Paroxetine hydrochloride ≥98%

Supplier: Enzo Life Sciences

Highly potent and selective serotonin uptake inhibitor

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Bupropion hydrochloride ≥98% (by TLC)

Supplier: Enzo Life Sciences

Inhibitor of dopamine and norepinephrine transporters

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N-(1-Adamantyl)-N'-cyclohexylmorpholine-4-carboxamidine hydrochloride ≥98%

Supplier: Enzo Life Sciences

K+ channel blocker

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Mono-n-dodecyl phosphate ≥98% (by TLC), white to off-white solid

Supplier: Enzo Life Sciences

Lysophosphatidic acid (LPA) receptor ligand. A specific agonist at LPA2 (EC₅₀=700 nM) and antagonist at LPA.

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[pSer95, Ala97]-RII (81-99)

Supplier: Enzo Life Sciences

Calcineurin substrate

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Sivelestat sodium ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.

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PF-356231 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.