Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: JULABO GmbH

Ultra-low temperature refrigerated circulators for heating and cooling. The units are suitable for external temperature applications with simultaneous operation in the bath tank. The units provide particularly high heating and cooling capacities for rapid heating and cooling times even for large volume, external systems. FP models offer proportional cooling control to ensure energy saving performance and to reduce heat generation to the environment. Models with the designation W are water cooled. All models have handles and castors which allow easy transportation and drain ports for conveniently draining the bath fluid. The units offer an improved insulation to prevent ice formation and have a filling level display. Typical applications: Temperature control of jacketed reaction vessels, autoclaves, mini plant installations, kilo labs, freezing point determination, calibration at low temperatures and petroleum testing.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: ProSci Inc.

The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Supplier: ProSci Inc.

FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Variant 1 (isoform a) encodes the longest transcript. Variant 2 (isoform b) contains an alternate exon, which results in an early stop codon, compared to variant 1. Isoform b has a shorter C-terminus when compared to isoform a. Mutations in this gene are the most common cause of Fanconi anemia.

Supplier: Thermo Scientific

ANGLE 1 * 1 items

Supplier: PARKER HANNIFIN

OUTLET PRESSURE REGULATOR 1 * 1 items

Supplier: Thermo Scientific

STACKING FOOT 1 * 1 items

Supplier: Zellstoff-Vertriebs-GmbH & Co. KG

WIPER BOWL ABRASIV DISPENSERCONT. 6X72PC 1 * 432 items

Supplier: Sartorius Balances

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions.

Supplier: LMS

LMS Series 1A cooled incubators are temperature controlled cabinets with fan assisted air circulation via a pre-mixing chamber. The units have a white enamelled sheet steel exterior, white pre-coated aluminium interior and polyurethane foam insulation, and feature a door lock and magnetic door gasket. The inner chamber is easy to clean, disinfection procedures are detailed in the user manual.

Supplier: BioAir S.p.A.

FILTER FIRST STAGE FOR SAFEMATE CYTO 1.2 1 * 1 items

Supplier: CEMO

LID FLAT FOR GRP RECTANGULAR CONTAINER 3 1 * 1 items

Supplier: TRESTON

Suspension rail with table top fixing, light grey 1 * 1 items

Supplier: Zellstoff-Vertriebs-GmbH & Co. KG

WIPER-BOWL MULTITEX 1 * 6 items

Supplier: LMS

LMS Series 4 cooled incubators are temperature controlled cabinets with fan assisted air circulation via a pre-mixing chamber. The units have a stainless steel exterior, stainless steel lined interior with polyurethane foam insulation, and feature a door lock and magnetic door gasket. Corrosion resistant inner chamber is easy to clean, disinfection procedures are detailed in the user manual.

Supplier: ProSci Inc.

During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 kDa) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.

Supplier: G-Biosciences

Plasmid Screening ToothPick™ allows the rapid screening of bacteria for transformed plasmids. Simply pick a colony, add to Plasmid Screening ToothPick™ reagents and then analyse using restriction enzymes.

Supplier: Heidolph Instruments GmbH & Co.KG

Hei-VAP Expert Control rotary evaporators allow central control of all process parameters: Vacuum, cooling temperature, rotation and heating bath temperature. The units have separate knobs for quick access: Right for direct vacuum control, the left one for rotation has a lock function to prevent accidental adjustment

Supplier: CAPITAL SAFETY

3M™ DBI-SALA® Davit Arm HC, Short reach davit arm HC (14 -28 ) 1 * 1 items

Supplier: MOTIC

Microscopes for basic work in biology life science. Fixed Koehler set-up gives adequate power resources for upgrading the microscope with contrast methods like phase contrast, polarisation or darkfield. The Motic BA 210 is a robust, ready to use with pre-installed set-up of optics and 3 W LED illumination.

Supplier: LMS

LMS Series 2 cooled incubators are temperature controlled cabinets with fan assisted air circulation via a pre-mixing chamber. The units have a white enamelled sheet steel exterior, high impact plastic interior and polyurethane foam insulation, and feature a door lock and magnetic door gasket. The corrosion resistant inner chamber is easy to clean, disinfection procedures are detailed in the user manual.

Supplier: GRANT INSTRUMENTS

The Grant Optima™ range consists of both general purpose and advanced performance thermostats combined with premium stainless steel baths (drain tap on 12, 18, 26 and 38 litre baths). Stirred circulation within the bath ensures excellent temperature stability and uniformity. Units can also be used with accessory C1G and C2G immersion coolers for operation below ambient temperatures.

Supplier: Thermo Scientific

Thermo Scientific CultiMaxx Shelving Systems are designed for use in Heracell VIOS 250i or Heracell Vios 250i Cleanroom CTS Series CO₂ incubators to support scale-out of Thermo Scientific™ Nunc™ Cell Factory™ systems in cell therapy production and are ideal for use with Wilson Wolf G-Rex® 500M-CS bioreactors, standard Nunc Cell Factory system or the Thermo Scientific™ Nunc™ EasyFill™ Cell Factory™ system, both with 4 layers.

Supplier: ProSci Inc.

Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome. A BLAST analysis was used to suggest crossreactivity with Jagged-1 protein from human, chimpanzee, rat and mouse based on 100% homology with the immunizing sequence. Partial reactivity is expected against canine (81%) and Xenopus laevis (85%) based on partial sequence homologies as indicated. The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Supplier: ProSci Inc.

ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.

Supplier: ProSci Inc.

Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.

Supplier: LEICA MICROSYSTEMS

The Leica DM IL is a fluorescence-ready digital imaging solution designed for use in a variety of laboratory settings including cell culture, micromanipulation, immuno staining and routine live imaging.

Supplier: JOUAN

KIT CONTRACT/REL OVEN EU500/720 1 * 1 items