97920 Results for: "Magnesium+tert-butoxide&pageNo=25&view=list"

Removing excess dye terminator is an essential step prior to Sanger sequencing. Carryover of the excess dye into the sequencing reactions may result in dye blobs resulting in inaccurate results. The AxyPrep™ Mag DyeClean kit utilises a paramagnetic bead-based purification system for Sanger sequencing reaction dye terminator clean-up. The protocol is simple and comprises binding, washing and elution steps which can be performed directly in the thermal cycling plate. This kit requires no centrifugation or filtration steps.

Expand 4 Items

BURETTE PTFE S/COCK CLASS A 25MLX0.05ML 1 * 1 items

Supplier: Poulten & Graf

BURETTE PTFE S/COCK CLASS A 25MLX0.05ML 1 * 1 items

Expand 1 Items

SAMPLE CELL 1INCH SQUARE25ML MATCHEDPAIR 1 * 1 items

Supplier: Hach

SAMPLE CELL 1INCH SQUARE25ML MATCHEDPAIR 1 * 1 items

Expand 1 Items

CLIP FOR JOINTS STAINLESS STEEL ST 1 * 1 items

Supplier: witeg Labortechnik

CLIP FOR JOINTS STAINLESS STEEL ST 1 * 1 items

Expand 1 Items

Middle plate 90-130/150 L=150 1 * 1 items

Supplier: TRESTON

Middle plate 90-130/150 L=150 1 * 1 items

Expand 1 Items

SAFETY VALVE COMPLETE 1/2 INCH (15MM) 1 * 1 items

Supplier: Priorclave

SAFETY VALVE COMPLETE 1/2 INCH (15MM) 1 * 1 items

Expand 1 Items

Anti-S100A8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Supplier: Bioss

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. .

Expand 1 Items

TIME TAPE 1 X 216 YELLOW IMPRINTED 1 * 6 Roll

Supplier: PRECISION DYNAMICS TIMEM

TIME TAPE 1 X 216 YELLOW IMPRINTED 1 * 6 Roll

Expand 1 Items

SOC SCREW FOR 811 20-25L 1 * 1 items

Supplier: Socorex Isba

SOC SCREW FOR 811 20-25L 1 * 1 items

Expand 1 Items

E.Z.N.A.® Universal Pathogen DNA Kit

Supplier: OMEGA BIO-TEK

The E.Z.N.A.® Universal Pathogen Kit allows for the rapid and reliable isolation of high quality host genomic DNA, gram positive and negative bacterial DNA, fungal spore DNA and viral DNA and viral RNA from tissue, urine, serum and fecal samples.

Expand 2 Items

Sodium deoxycholate monohydrate ≥98%

Supplier: Thermo Fisher Scientific

Sodium deoxycholate monohydrate ≥98%

Expand 1 Items

Anti-High-mobility group Protein box 1/HMGB1 Mouse Monoclonal Antibody [clone: B1F3]

Supplier: Biosensis

High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).