4524 Results for: "MARKET+SOURCE+PART+PROCESS&pageNo=61&view=easy"

Supplier: Bioss

Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (13), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerise with members of the class A and B HLH proteins (15). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Supplier: Bioss

DCAKD belongs to the coaE family. It contains one DPCK (dephospho CoA kinase) domain. There are two isoforms.Coenzyme A (CoA) is an essential cofactor used in numerous biochemical pathways. It plays a critical role in the synthesis and oxidation of fatty acids and is vital to the citric acid cycle. The biosynthesis pathway of CoA from pantothenic acid (also known as vitamin B5) is essential and universal in prokaryotes and eukaryotes. In humans, the final steps of the biosynthesis pathway are carried out by the bifunctional enzyme COASY. The sequence of these enzymes are highly conserved between different bacterial species. The phosphopantetheine adenylyltransferase and decoenzyme A kinase activities of COASY are evolutionarily conserved activities. DCAKD (deCoA kinase domain containing protein) is a 231 amino acid protein that consists of a deCoA kinase domain and an ATP nucleotide binding motif. Localising to mitochondria and the cytosol, DCAKD belongs to the coaE family which suggests that it may play a role in the biosynthesis of CoA.

Supplier: LEICA MICROSYSTEMS

Leica (brightfield) colour cameras provide outstanding colour fidelity due to state-of-the-art colour interpolation algorithms performed in the camera head. Leica fluorescence cameras provide high sensor sensitivity allowing short exposure times and, therefore, preventing photo bleaching, so actively protecting cells from any photo damage.

Supplier: Bioss

DCAKD belongs to the coaE family. It contains one DPCK (dephospho CoA kinase) domain. There are two isoforms.Coenzyme A (CoA) is an essential cofactor used in numerous biochemical pathways. It plays a critical role in the synthesis and oxidation of fatty acids and is vital to the citric acid cycle. The biosynthesis pathway of CoA from pantothenic acid (also known as vitamin B5) is essential and universal in prokaryotes and eukaryotes. In humans, the final steps of the biosynthesis pathway are carried out by the bifunctional enzyme COASY. The sequence of these enzymes are highly conserved between different bacterial species. The phosphopantetheine adenylyltransferase and decoenzyme A kinase activities of COASY are evolutionarily conserved activities. DCAKD (deCoA kinase domain containing protein) is a 231 amino acid protein that consists of a deCoA kinase domain and an ATP nucleotide binding motif. Localising to mitochondria and the cytosol, DCAKD belongs to the coaE family which suggests that it may play a role in the biosynthesis of CoA.

Supplier: Bioss

Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (13), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerise with members of the class A and B HLH proteins (15). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Supplier: Bioss

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Supplier: Bohlender

To prevent your waste canister from overflowing, connect these b.safe waste caps with electronic fill-level control to the alarm box. When the 'canister full' level is reached, you will receive an optical and acoustic warning. The alarm is triggered before your canister is completely full. This leaves a small safety buffer in the canister.

Supplier: Merck

Milli-Q® IQ Element water purification and dispensing unit is designed to fit into your trace analysis workflow. The Milli-Q® IQ Element unit, combined with a Milli-Q® IQ 7 series water purification system, delivers analytical grade ultrapure water that is suitable for trace and ultra-trace elemental analyses, including ICP-MS, GF-AAS and trace IC.

Supplier: LEICA MICROSYSTEMS

Ivesta 3 – For inspection and rework only, but no camera for documentation is needed.
Ivesta 3 with C-mount – Gives you the flexibility to add a camera if needed and thus turn it into a digital microscope solution.
Ivesta 3 with integrated camera – For digital image sharing directly on different devices, such as, a monitor, mobile device, or computer.

Supplier: Bioss

Alpha-lactalbumin is the B protein of lactose synthetase secreted by the mammary epithelial cells. It is a potent Ca2+-elevating and apoptosis-inducing agent with broad, yet selective, cytotoxic activity. Multimeric lactalbumin has been shown to kill all transformed, embryonic and lymphoid cells tested, but not mature epithelial elements. This suggests that milk contributes to mucosal immunity not only by furnishing antimicrobial molecules but also by policing the function of lymphocytes and epithelium. ?lactalbumin may be helpful in discovering the site of origin of metastatic breast tumours. Human lactalbumin contains 123 amino acid residues. Comparison of the 5' flanking sequences of the two Alpha-lactalbumin genes with those of five casein genes reveals the presence of a highly conserved region extending from position -140 to -110 in all seven sequences examined, suggesting a possible regulatory role in the hormonal control or tissue-specific expression of milk protein genes in the mammary gland.

Supplier: IKA

The INC 125 FS digital incubator shakers have a removable shaker platform. Without the platform, the units can be used as a normal incubator. The large inner chamber with a volume of 125 L offers space for up to 6 grid shelves (without shaker platform). Thanks to high temperature stability and a uniform shaking motion that improves oxygenation, the incubator shakers are the perfect solution for cell cultivation and other microbiological applications.

Supplier: Thermo Scientific

Thermo Scientific™ TDE Series ‒40 °C ultra-low temperature freezers, powered by H-drive, feature three upright models, maximizing storage capacity from 40000 up to 60000 2 ml vials. The TDE Series is a sustainable and reliable solution with ultimate sample security and operational savings for every laboratory.

Supplier: Biotium

Label your antibody with one of our superior CF® Dyes in 30 minutes without a purification step. Labelling tolerates many common buffer components including BSA and ascites.

Supplier: Bioss

The leucine-rich (LRR) repeat is a 20 to 30 amino acid motif that forms a hydrophobic å/ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. SLITRK3 (SLIT and NTRK-like family, member 3) is a 977 amino acid single-pass type I membrane protein that contains 20 LRR repeats and belongs to the SLITRK family. Expressed at highest levels in cerebral cortex, SLITRK3 is also found in adult and fetal neural tissues and some astrocytic brain tumours. SLITRK3 functions to suppress neurite outgrowth and plays a role in the regulation of neuronal function. SLITRK3 is encoded by a gene that maps to human chromosome 3, which houses over 1100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Supplier: VWR Collection

Designed for a variety of shaking applications such as cell cultures, solubility studies, bacterial suspensions and general mixing. Large capacity platform holds up to 15,9 kg. Variable speed, microprocessor control provides consistent, uniform mixing action. Ramping feature slowly increases speed to the set point for added safety. The Accu-drive shaking system delivers exceptional speed control, accuracy, safety and durability. System continuously monitors shaking speed and will maintain the set point even under changing loads. Displayed speed is accurate to 1% of set speed (when speed is above 100 min⁻¹).

Supplier: Thermo Fisher Scientific

The Thermo Scientific™ IntelliStack™ Incubator shaker is a versatile laboratory instrument used for incubating and agitating samples simultaneously. It combines the functions of an incubator and shaker, providing a controlled environment for cell culture, microbial growth, and various other applications. With adjustable temperature, speed, and humidity settings, it offers precise control over experimental conditions. A large, easy-to-use 10" colour touchscreen display with real-time monitoring of key parameters and alarms, alerts, and data logging with export via USB or Ethernet allows easy operation, enabling users to set and maintain specific temperature, speed, humidity level, and duration parameters to meet the requirements of various applications.

Supplier: VWR Collection

VWR® Imager gel documentation and analysis systems are available in configurations suitable for fluorescence and chemiluminescence applications. Both models are fitted with a digital CCD camera (3,8 or 4 MP) which utilises the latest USB technology. The standard system features a 12-bit CCD camera that can be software modified to 16-bit. The CHEMI Premium system is equipped with a true 16-bit advanced cooled CCD camera able to capture images of a wide range of chemiluminescent samples using common substrates.

Supplier: Sartorius Balances

Semi-micro balances have a readability of 0,01 mg or 10 µg and a maximum weighing capacity of up to 220 g.

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf94 gene product has been provisionally designated C1orf94 pending further characterisation.

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf94 gene product has been provisionally designated C1orf94 pending further characterisation.

Supplier: Bioss

Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.

Supplier: Avantor Fluid Handling

High-flow pump for process applications – with an intuitive touch-screen interface and advanced connectivity.

Supplier: Avantor Fluid Handling

Versatile pumps for process applications – with an intuitive touch-screen interface and advanced connectivity.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: Whatman products (Cytiva)

Mixed cellulose ester, WME range, circles, gridded. Whatman mixed cellulose ester membranes are composed of cellulose acetate and cellulose nitrate. These membranes are characterized by a smoother and more uniform surface than pure nitrocellulose filters.

Supplier: FRISTADS KANSAS

Thanks to its durability and high degree of comfort, the PR54 jacket is perfectly suited to workshops and industrial and service enterprises. The material is made from 65% polyester and 35% cotton. The inside is brushed and as a result conveys a pleasantly comfortably cotton feeling. The outside is also resistant to the roughest demands and will not fade even after countless washes.

Supplier: FRISTADS KANSAS

Thanks to its durability and high degree of comfort, the PR54 jacket is perfectly suited to workshops and industrial and service enterprises. The material is made from 65% polyester and 35% cotton. The inside is brushed and as a result conveys a pleasantly comfortably cotton feeling. The outside is also resistant to the roughest demands and will not fade even after countless washes.

Supplier: FRISTADS KANSAS

Trousers made of 65% polyester and 35% brushed cotton. The fabric has mechanical stretch, which ensures improved comfort, especially for jobs that require a lot of movement.

Supplier: Bel-Art Products, a Part of SP

The box style design of the ampoule opener allows one handed opening of up to 3 ampoules at a time by simply pressing down on lid. Ampoule necks are snapped clean and are contained within the device while fingers stay away from sharp edges. After removing ampoule contents, turning the device upside down over a trash receptacle can safely discard ampoules and tops. Made from transparent copolyester plastic.

Supplier: Thermo Fisher Scientific

This RO system with controller provides easy-to-read system parameters. Completely drainable, integrated 100 L high-purity water reservoir has a low-noise pressure booster as a standard component. The compact LabTower RO system is ideally suited as a feed water source for dishwashers, autoclaves and general laboratory use. It serves as a built-in pretreatment unit, consisting of a hardness stabilizer for protection of reverse osmosis module from hardness formers. An activated carbon/5 μm combi-cartridge protects the system against free chlorine and particles which ensures the long service life of downstream purification stages.