Supplier: Corning

CoolCell® alcohol-free cell freezing containers ensure standardised controlled-rate −1 °C/minute cell freezing in a −80 °C freezer, without alcohol or any fluids.

Supplier: GILSON

Designed for performance and comfort, PIPETMAN® L comes in a comprehensive range of models, adapted to your needs in the lab. PIPETMAN L air-displacement pipettes cover a full volume range. Comfortable, precise, accurate, and reliable, use PIPETMAN L pipettes confidently in your applications.

Supplier: VWR Collection

The ILCO 180 and ILCO 260 Premium offer optimal growth conditions for cell cultures and meet demanding requirements for best possible cell growth and maximum sample safety. These CO₂ incubators come with a built-in, drift-free infrared CO₂ sensor that can be sterilised. Reliable decontamination is provided by the standard-compliant 180 °C hot air sterilisation routine which completely eliminates contaminants and ensures the inner chamber is completely sterilised. They have an intuitive menu and user friendly software, also USB port for data download to USB stick and for uploading programs. They can be connected to Ethernet or Wi-Fi networks for remote control from any computer, and users can receive notifications about alarms/events via e-mail.

Supplier: ProSci Inc.

MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Supplier: VWR Collection

These compressor-cooled incubators provide a temperature range between –10 to +100 °C with forced air convection and fan speed control (10 to 100%). Featuring a stainless steel (DIN 1.4301) inner chamber and a powder coated sheet exterior. PREMIUM models have an intuitive menu and user friendly software, USB port with flash drive for data download to USB stick and for uploading programs. They can be connected to Ethernet or Wi-Fi network for remote control from any computer and users can receive notifications about selectable parameters via e-mail.

Supplier: Priorclave

These autoclaves combine a huge internal capacity with a small floor area and are ideally suited for use in a wide range of sterilising applications such as media preparation, liquids and diluent, waste, glassware, instruments and apparatus. They are extensively used within many industries, including food, drink, dairy, pharmaceutical, agricultural, education, healthcare, research establishments and industry. All Priorclaves come complete with Biomaster antimicrobial coating, helping improved laboratory hygiene; it is effective against all bacteria and fungi including MRSA and therefore helps minimise the risk of cross contamination.

Supplier: VWR Collection

The XT family of VWR® PCR thermal cyclers combine industry- and customer-inspired innovation housed in a robust, low noise design that fits on virtually any bench top. The fast ramping 96-well block is accurately controlled by eight Peltier elements ensuring reproducible PCR results and offering a gradient PCR option. Making use of advanced technology, XT cyclers can be connected via Ethernet and controlled remotely by a primary XT⁹⁶ cycler, a PC or a mobile device (smartphone/tablet). The software/App needed comes free and provides the same intuitive user interface as the touch-sensitive, sharp 7" TFT display that the XT⁹⁶ cycler is equipped with. When used as part of a remote control configuration, the XTender⁹⁶ makes a perfect secondary unit, having no built-in display, but reduced to its core function of providing excellent PCR results, while saving costs and valuable resources. Other innovative features:

Supplier: ProSci Inc.

FUNCTION: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
SUBUNIT: Ligand for integrin beta-V/gamma-3.
SIMILARITY: Contains 1 peptidase M12B domain.
SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein (Potential). Secreted protein. Isoform Gamma.
TISSUE SPECIFICITY: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
DEVELOPMENTAL STAGE: Highly expressed in the fetal brain.
DOMAIN:A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
SUMMARY: This protein is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is highly expressed in the brain and may function as an integrin ligand in the brain.

Supplier: MOTIC

Panthera E2 microscope combine high quality materials and precise engineering, user-friendly design. With a 360º rotatable head specially for space-saving storage, and an extreme efficient low power illumination, allowing it to run on a Mobile Battery Pack for several hours. It has been designed for Academic Lab demand.

Supplier: ENZO LIFE SCIENCES

CaMKIIa, the alpha subunit of Ca2+ calmodulin-dependent protein kinase II is part of a family of multifunctional protein kinases, which play a major role in Ca2+-mediated signal transduction.  CaMKIIa is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites as well as the soma of the neuron.  The neuronal CaMKII consists of two major subunits of 52 and 60 kDa which are encoded by a- and b-CaMKII genes, respectively.  Additional isoforms are generated by alternative splicing of these as well as of the ubiquitious g- and d-CaMKII genes.  Each subunit has an ATP-binding domain (arginine-X-X-serune/threonine), consensus phosphorylation site, catalytic domain, and a centrally located regulatory domain which has calmodulin binding activity. Activation and autophosphorylation of CaMKII may regulate numerous neuronal processes which includes two forms of synaptic plasticity, long term potentiation and long term depression.  Neuronal CaMKII subunits assemble as large multimeric holoenzymes.  The C-terminal association domains of  6-12 subunits assemble into a central globular structure from which the N-terminal catalytic/regulatory domains extend radially like petals of a flower. The subunit composition of the rat forebrain CaMKII holoenzyme consists of heteromers composed of a and β subunits at a ratio of 2:1 and homomers composed of only a subunits.  The association of CaMKII subunits leads to the positioning of their catalytic/regulatory domains in close proximity and the neighboring calmodulin-bound subunits cooperate to rapidly phosphorylate each other.  Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities.

Supplier: Thermo Scientific

This biological safety cabinet combines smart design and extraordinary value with best in class energy efficiency, reliability and usability. The advanced design of the MSC-Advantage biological safety cabinet improves overall operation and maintenance, maximises safety and optimises service and clean-up. With advanced internal airflow and motor technology, MSC-Advantage cabinets offer optimal energy efficiency, operation and serviceability. At full speed the motors consume 60% less energy than standard cabinets. To further conserve energy, the intelligent speed control automatically reduces blower speed to 30% when the window is closed. This technology extends HEPA filter life while ensuring a sterile working environment and saves energy to minimise operating costs.

Supplier: Liebherr

Glass/steel door high-volume refrigerators with forced air cooling. White steel exterior and stainless-steel interior. Choose between two temperature stability options to suit differing lab requirements. The intuitive user interfaces provide useful extended multi-functionality, e.g. a maintenance timer, and the LED interior lighting ensures good visibility of the contents of these large appliances. Advanced connectivity options to suit varying requirements for simplified data storage, temperature control and alarm signals. These advanced lab fridges also feature a +2 °C safety device to protect sensitive contents from freezing.

Supplier: Biosensis

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

Supplier: Thermo Fisher Scientific

Pierce silver stain rescue reagent enables removal of undesirable background from unevenly and overly developed silver-stained polyacrylamide electrophoresis gels.

Supplier: IKA

TWISTER is a universal and compact mixing device with magnetic drive. In the default version, TWISTER is a powerful single-position magnetic stirrer for mixing up to 5 litres at a maximum speed of 3000 min⁻¹ and a viscosity of up to 500 mPa·s. By connecting additional TWISTER stirring units (available as accessories, IKAA20112621), TWISTER can be expanded to a multi-position magnetic stirrer with up to 30 stirring positions. The stirring positions can be controlled either separately or simultaneously (leader-follower principle).

Supplier: ProSci Inc.

This antibody recognises human blood group A (monofucosyl and difucosyl A antigens with chain types 1, 2, 3, 4, 5, 6) and Forssmann antigen. It is also reactive with the immuno-dominant A trisaccharide. Blood group antigen expression in human colon cancer was studied by means of two monoclonal antibodies of broad anti-A (HE-14) and anti-type 3 and type 4 chain-based A and H (HE-10) specificity. These antigens were proved to re-appear in tumors of the distal colon, the HE-10 antibody reacting more frequently (9 out of 12 samples) than HE-14 (5 out of 12 samples) and frequently with supra-nuclear staining of the cytoplasm probably in those places of the Golgi apparatus where carbohydrate antigens are synthesised. This staining pattern is characteristic of HE-10 in normal colonic mucosa as well. With HE-14, staining was often absent in less differentiated tumors, while HE-10 did react in such tumors. In some cases, these two antibodies gave different staining patterns in parallel sections from the same tissue sample, primarily at the cellular level. Three out of 12 cases showed blood group antigen expression in the mucosa of the distal colon adjacent to the tumor only when HE-10 mAb was used.

Supplier: Thermo Fisher Scientific

In order to maintain cellular viability during the freezing process, certain cells such as protist, mammalian, and plant cells require precise control of the freezing rate in order to minimize the detrimental effects of undercooling and the heat liberated during the phase change process from water to ice. The Thermo Scientific™ CryoMed™ Controlled-Rate Freezers (CRFs) are designed with reliability, protection, and data traceability in mind for sample preparation and GMP production needs.

Supplier: VWR Collection

The VWR® Constant climate chambers with Peltier technology feature excellent variation and fluctuation values for temperature and humidity. They are energy efficient and environmentally friendly, with a low noise level, and they work almost vibration-free as no compressor is installed. These models, with forced air convection, provide a temperature range between 0 to +70 °C (max. 20 °C below ambient) and feature a stainless steel (DIN 1.4301) inner chamber and stainless steel housing, solid outer door and internal glass door. The PREMIUM models have an intuitive menu and user friendly software and a USB port with flash drive for data download to USB stick and for uploading programs. They can be connected to an Ethernet or Wi-Fi network for remote control from any computer, and users can receive notifications about selectable parameters via e-mail.

Supplier: G-Biosciences

Determination of protein concentration is an essential technique in all aspects of protein studies and proteomics. The Assays for Protein Quantification kit includes three of the most widely used protein assays and allows for a direct comparison of the three assays that teaches students the benefits and limitations of each assay. Each assay is available individually to allow teaching of a specific assay, without the option of comparing and contrasting with other assays. The three assays covered are the Biuret Protein Assay, Lowry Protein Assay and the Coomassie Blue Dye Protein Assay. The Assays for Protein Quantification kit provides all the reagents required to perform both protein assays, including protein standards for accurate quantification, in a single lab activity. An often underestimated factor in quantifying protein is the presence of non-protein interfering agents, such as salts and detergents. This kit teaches students about common laboratory agents that affect the protein assays, the reasoning behind their interferences and how to overcome the interference. Students also learn how to select a protein assay for different applications.

Supplier: Mettler - Toledo

Portable dual channel meters for the simultaneous determination of pH, mV, rel. mV, ion (SG78), conductivity, TDS (total dissolved solids), salinity or specific resistance.

Supplier: VWR Collection

Cooled incubators with Peltier technology feature excellent temperature stability and uniformity. They are energy efficient and environmentally friendly, with a low noise level, and they work almost vibration-free as no compressor is installed. No dehumidification of samples due to the closed chamber. These models, with forced air convection, provide a temperature range between 0 to +70 °C (max. 20 °C below ambient) and feature a stainless steel (DIN 1.4301) inner chamber and stainless steel housing, solid outer door and internal glass door. The PREMIUM models have an intuitive menu and user friendly software and a USB port with flash drive for data download to USB stick and for uploading programs. They can be connected to an Ethernet or Wi-Fi network for remote control from any computer, and users can receive notifications about selectable parameters via e-mail.

Supplier: ENZO LIFE SCIENCES

CD40 is a 45-50 kDa type I membrane protein and a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 is also known as pb50 or CDW40.  CD40 is expressed primarily by professional antigen-presenting cells and it is also expressed on non-immune cell types. The CD40 expressed by professional antigen-presenting cells plays a critical role in co-stimulation and antigen-presenting cell activation in T cell-dependent immune responses. Signals generated through CD40 in B cells are anti-apoptotic. These signals are also required for T cell-dependent B cell activation and proliferation, isotype switching, up-regulation of costimulatory receptors, germinal center formation and memory generation. CD40 signal transduction is initiated by binding trimeric CD40 ligand (CD40L) which is found on the surface of activated T cells.  CD40 engages several signalling pathways in B cells and these include NF-kB, the mitogen-activated protein kinases p38 and c-Jun N-terminal kinase. The 62 amino acid cytoplasmic domain (CD40c) of CD40 contains two linear TNF-receptor associated factor (TRAF) binding domains. The membrane proximal site of CD40c binds TRAF6 and the membrane distal site binds TRAF1, 2 and 3. CD40c is thought to mediate the CD40-dependant signalling pathways by recruitment of TRAF to this multimerized domain. CD40 ligation has also been shown to stimulate iNOS expression, and therefore NO production, by activating NF-kB in IFN-g treated microglial cells. NO derived from microglia has been implicated in the damage of myelin-producing oligodendrocytes in demyelinating disorders like multiple sclerosis (MS) and neuronal death during Alzheimer’s disease and brain trauma. Increased CD40-CD40 ligation has been implicated in the pathogenesis of several autoimmune inflammatory diseases, such as MS, arthritis and insulin-dependant diabetes.

Supplier: MOTIC

Panthera C2, Motic's new upright microscope range, revolutionises the conventional microscope concept by creating a smart microscope. Its design, together with its new optics and digital capabilities, makes it the microscope of tomorrow. Your perfect lab mate.

Supplier: LMS

LMS Series 4 cooled incubators are temperature controlled cabinets with fan assisted air circulation via a pre-mixing chamber. The units have a stainless steel exterior, stainless steel lined interior with polyurethane foam insulation, and feature a door lock and magnetic door gasket. Corrosion resistant inner chamber is easy to clean, disinfection procedures are detailed in the user manual.

Supplier: ENZO LIFE SCIENCES

The Hsp60 of Heliothis viescens belongs to a highly conserved family of molecular chaperones from several species, including plant Hsp60 (known as Rubisco binding protein), GroEL, the E.coli Hsp60, and 65 kDa major antigen of mycobacteria. In eukaryotes, Hsp60 is localized in the mitochondrial matrix, and in plants Hsp60 is localized in the chloroplast. Mitochondria, chloroplasts and bacteria share a common ancestry (>1 billion years), and this coupled with the high degree of homology between the divergent Hsp60s suggests that these proteins perform a primitive but vital function similar to all the different species. The common characteristics shared by the Hsp60s from the divergent species include high abundance; induction with environmental stress such as heat shock; homo-oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg2+ and ATP; ATPase activity; and a role in folding and assembly of oligomeric protein structures. Studies support these similarities, showing expression of the single-ring human mitochondrial homolog Hsp60 with its co-chaperonin Hsp10, in a E. coli strain engineered so that the groE operon remained under strict regulatory control. The findings demonstrate that expression of Hsp60-Hsp10 enabled successful performance of all essential in vivo functions of GroEL and its co-chaperonin, GroES. Consistent with their functions as chaperones, Hsp60 and Hsp10 may act as docking molecules with a passive role in the maturation of caspase processing. Data incidates that recombinant Hsp60 and Hsp10 accelerate the activation of procaspase-3 by cytochrome c and dATP in an ATP-dependent manner. Hsps are intracellular proteins thought to serve protective functions against infection and cellular stress; however, several studies reveal a possible link between members of the Hsp60 and a number of autoimmune diseases, atherosclerosis, and chlamydial disease.

Supplier: LABORIAL

Innovative interactive worktop for laboratories, cleanrooms and healthcare. A hygienic design based on GMP guidlines which consists of a continuous, tempered glass surface on phenolic resin laminate in which is embedded a touch control screen, to provide an interactive worktop, all supported on a metallic structure. At the same time, it works as a regular worktop and solves the disinfection and contamination problems associated with the use of tablets, notebooks, PCs, keyboards and mouse in cleanrooms and other controlled environments. It allows access to any laboratory software such as electronic notebooks, LIMS, Wikis, analysis software, Office and others, on the laboratory workbench, whilst maintaining an aseptic environment. The interactive worktop can help to reduce traffic, in and out of critical areas in which the use of handheld computer devices are restricted or prohibited.

Supplier: MP Biomedicals

Potassium sodium tartrate tetrahydrate has been used in organic synthesis to break up emulsions in aqueous workups.

Supplier: VWR Collection

These PCR tube strips and caps are made of PP resin and are designed to fit most popular brands of thermal cyclers.

Supplier: Brand

PP. Eight connected 0,2 ml tubes with attached domed cap strips.

Supplier: Brand

PP. Eight connected 0,2 ml tubes and domed or flat caps in strips of eight.