145769 Results for: "LGC+Standards+PROMOCHEM&pageNo=10&view=list"

Supplier: ProSci Inc.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Supplier: ProSci Inc.

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Supplier: Portwest

A great value addition to the multi-protection range, the S774 jacket is a lightweight, unpadded garment hosting a multitude of functional features and benefits.

Supplier: Portwest

A classic jacket with good fit to streamline and reduce the bulkiness women often feel in a fourseason jacket. The longer line back panel and discreet waist adjustment make this a contemporary silhouette and give a flattering smooth front jacket.

Supplier: ProSci Inc.

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Supplier: ProSci Inc.

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Supplier: ProSci Inc.

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Supplier: Portwest

These overalls are made from 300D Oxford Weave fabric (300 denier polyester yarn) which features a high abrasion and tear resistance. The PU coating on the inside makes the fabric durable and waterproof, while the outer has a water- and stain-repellant coating which helps keep the garment clean. Ideal for use in dark, cold and wet conditions.

Supplier: EPPENDORF

Eppendorf twin.tec® real-time PCR plates, designed for low-volume qPCR, utilise white wells to enhance fluorescent light reflection, improving sensitivity and reproducibility in assays for reliable results.

Supplier: Portwest

Contemporary work jacket made from a soft knitted fleece fabric. Reinforced shoulders and back panels offer added durability in heavy-use areas. Interchangeable zip pullers in blue, red and lime green are supplied for easy integration of corporate colours. Designed with a modern fit, this jacket hosts a range of practical features including a longer back length, a rubber zip puller and multiple pockets.

Supplier: Portwest

The DX4 zipped hoodie is innovative and technical with a two-faced fabric that provides lightweight warmth and unrestricted movement. Two zipped chest and side entry pockets offer plenty of secure storage space. The full zip on the front has a rubber puller for easy grip and the adjustable hood provides a close fit. A contemporary option for the modern worker.

Supplier: Portwest

These premium jackets provide super comfort in all weathers and specially engineered for maximum performance. Waterproof and breathable to the highest standards, these jackets boast a multitude of features including six pockets for convenient storage and a full length superior two-way zip fastening.

Supplier: Antibodies.com

Mouse Retinoic acid Receptor alpha ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Retinoic acid Receptor alpha in serum, plasma, and other biological fluids.

Supplier: PHOENIX BIOMEDICAL

Clear PS. Ideal for colony counting.

Supplier: Portwest

These fully waterproof anti-static bomber jackets provide multi-norm protection in hazardous conditions. These are designed with chemical resistance and a detachable hood.

Supplier: Portwest

The DX4 Baffle Gilet uses a body-mapped design to balance insulation and freedom of movement. Hard-wearing nylon front and back panels are padded with Insulatex to keep the core body area warm. Two zipped chest pockets, side entry pockets, and internal pockets offer plenty of secure storage space.

Supplier: Antibodies.com

Human TGF beta Receptor I ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human TGF beta Receptor I in serum, plasma, and other biological fluids.

Supplier: ProSci Inc.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.

Supplier: Antibodies.com

Porcine beta Nerve Growth Factor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of porcine beta Nerve Growth Factor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Rat Angiotensin II Type 2 Receptor ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat Angiotensin II Type 2 Receptor in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: ProSci Inc.

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Supplier: Antibodies.com

Human NF-kB p65 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human NF-kB p65 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Mouse Serum Response Factor SRF ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Serum Response Factor SRF in serum, plasma, and other biological fluids.

Supplier: ProSci Inc.

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

Supplier: Greiner Bio-One

VACUETTE® serum tubes are coated with micronised silica particles which activate clotting when tubes are gently inverted. These tubes are used for routine clinical chemistry, immunohematology, serology and immunology testing.

Supplier: Mettler - Toledo

The XP precision balances provide high productivity instruments with improved linearity, safety and security using MonoBloc ^HighSpeed technology. This is achieved with the introduction of QM toolbox, SmartSens and MinWeigh functions. This range is therefore particularly suited where regulatory compliance is required. Draught shields are standard on the small square platform size (see models denoted * in the table). The touch screen provides fast and easy access to all balance functions.

Supplier: ProSci Inc.

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRalpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Supplier: ProSci Inc.

Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al.,2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking (Hoffert et al., 2007).

Supplier: Portwest

Portwest WX3 contemporary workwear is designed to the highest standards and offer a solution for everyday activity and working environments. Constructed with cutting edge fabrics giving superior abrasion resistance and exceptional all-day comfort. The WX3 work trousers are made from durable poly-cotton canvas fabric and includes triple stitched seams and stretch panelling providing excellent comfort and flexibility.

Supplier: ProSci Inc.

There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (A and B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.