48170 Results for: "Hexachloroiridic+(IV)+acid&pageNo=8"

Supplier: Enzo Life Sciences

A potent and specific substrate analog PLA2 inhibitor (IC50=6.2 µM-porcine pancreatic PLA2). It inhibits human recombinant sPLA2 (IC50=13.7 µM) selectively over cPLA2. At 1 µM it completely blocked the myogenic response in perfused dog renal arcuate arteries.

Supplier: Enzo Life Sciences

Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.

Supplier: Enzo Life Sciences

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Supplier: Enzo Life Sciences

Inhibits ERK2 (Ki = 525nM). Also inhibits adenosine kinase (Ki = 30nM), CK1 and CK2 and insulin receptor kinase (IC50 ranging from 0.4-28µM).

Supplier: Enzo Life Sciences

Src kinase inhibitor

Supplier: Enzo Life Sciences

Phospholipase inhibitor

Supplier: Enzo Life Sciences

Inhibits Rho kinase (ROCK; Ki=0.33μM). Selective protein kinase A and G inhibitor (both Ki’s = 1.6μM). Inhibits agonist-induced activation of NADPH oxidase in human neutrophils (IC50=15μM). Inhibitor of myosin light chain kinase and Ca2+/calmodulin-dependent protein kinase II. Inhibits translocation of PKCβI, PKCβII and PKCζ. Cell permeable Ca2+ antagonist with antivasospastic properties.

Supplier: Enzo Life Sciences

MPTP inhibitor

Supplier: Enzo Life Sciences

Clinically useful diuretic. Clopamide selectively inhibits the chloride the sodium chloride cotransporter.

Supplier: Enzo Life Sciences

Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.

Supplier: Enzo Life Sciences

ADP-ribosylation factor inhibitor

Supplier: Enzo Life Sciences

A useful tool for affinity purification of HSP-90 and HSP-90 dependent client proteins.

Supplier: Enzo Life Sciences

NF-kappaB inhibitor

Supplier: Enzo Life Sciences

VEGF receptor tyrosine kinase inhibitor. Inhibits KDR (IC50=100nM) and Flt (IC50=2µM) tyrosine kinases.

Supplier: Enzo Life Sciences

Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.

Supplier: Enzo Life Sciences

Phospholipase inhibitor

Supplier: Enzo Life Sciences

Beneficial effect in cardiovascular diseases and inflammation. Inhibits PGE2 formation from arachidonic acid in 3T3 fibroblats.

Supplier: Enzo Life Sciences

A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. It suppresses atherogenesis and limits atherosclerotic lesion development in the rabbit. It reduces oxidant stress-induced apoptosis in endothelial cells and inhibits proliferation in 15-LO overexpressing PC3 cells.

Supplier: Enzo Life Sciences

GEF inhibitor

Supplier: Enzo Life Sciences

A myristate analog which has similar chain length but reduced hydrophobicity compared to myristate. Inhibits replication of HIV-1. Its specific mechanism of action is not clear but it is believed to either inhibit the activity of N-myristoyltransferase or modulate the function of target acylated proteins.

Supplier: Enzo Life Sciences

HMG-CoA reductase inhibitor

Supplier: Enzo Life Sciences

Prostanoid receptor ligand.

Supplier: Enzo Life Sciences

Endogenous lipid which significantly reduced food intake in a dose-dependent fashion when administered to rats and mice (100 mg/kg, i.p.), without causing taste aversion. Has been found to enter the brain (concentrating in the hypothalamus) when administered systemically and also reduced food intake when infused intracerebroventricularly (nanomolar concentrations). This suggests that mediation of effects is via the CNS. Chronic infusion resulted in a reduction of both food intake and body weight.

Supplier: Enzo Life Sciences

LPA receptor ligand

Supplier: Enzo Life Sciences

Phosphodiesterase PDE II inhibitor, IC50=0.8 µM. Also inhibits adenosine deaminase, Ki=4 nM.

Supplier: Enzo Life Sciences

PDE inhibitor

Supplier: Enzo Life Sciences

Selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I, IC50=4 µM).

Supplier: Enzo Life Sciences

PP2A inhibitor

Supplier: Enzo Life Sciences

Biosynthesis via hydrolysis of prostacyclin. A reliable parameter for measurement of prostacyclin. Ultra-pure.

Supplier: Enzo Life Sciences

ATPase inhibitor