209 Results for: "Formamide"

Supplier: ENZO LIFE SCIENCES

Specific, potent and membrane permeant activator of the Epac cAMP receptor.

Supplier: SIGMA ALDRICH MICROSCOPY

Kit used to detect neutrophils in peripheral blood, bone marrow or tissue sections which have been paraffin embedded.

Supplier: Cayman Chemical

Rebaudioside C is a natural non-caloric sweetener.

Supplier: G-Biosciences

These premixed and ready-to-use gel dyes are designed to minimise the use of ethidium bromide. Glow dyes provide intense DNA/RNA bands with little background or band distortion on any type of agarose or acrylamide gel.

Supplier: ENZO LIFE SCIENCES

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

Supplier: ENZO LIFE SCIENCES

Apoptosis inducer.

Supplier: MP Biomedicals

Non-ionic monomeric triiodinated x-ray contrast agent

Supplier: ENZO LIFE SCIENCES

RK-682 is a novel tyrosine phosphatase inhibitor isolated from Streptomyces sp. It inhibits the dual specificity VHR phosphatase (IC50=2.0µM) selectively over CD45 (IC50=54µM), Cdc25B and PTP1B (IC50~42µM). RK-682 inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea pig hippocampal CA1 neurons. Shows potent activity against HIV-1 protease.

Supplier: ENZO LIFE SCIENCES

Primary metabolite of arachidonic acid via the 12-lipoxygenase pathway. Inhibits thromboxane synthase. Inhibits platelet aggregation via activation of guanylate cyclase (100% at 5µM). Stimulates leukotriene biosynthesis. Potent and selective inhibitor of Ca2+-calmodulin-dependent protein kinase II (IC50=0.7µM). Endogenous TRPV1 agonist (Ki=0.35µM).

Supplier: ENZO LIFE SCIENCES

Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic.

Supplier: SIGMA ALDRICH MICROSCOPY

Stains-All has been used for the staining of gel made for size determination of hyaluronan. It has also been used for the staining of DNA oligonucleotides separated by nondenaturing polyacrylamide gel electrophoresis.

Supplier: ENZO LIFE SCIENCES

PKC activator (10 to 100 ng/ml).

Supplier: ENZO LIFE SCIENCES

Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.

Supplier: ENZO LIFE SCIENCES

Water soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·). The inhibitory effects were almost 2-fold stronger than those of NMMA and NOARG. Reacts with nitric oxide in a stoichometric manner. Can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent. Protects against endotoxin shock.

Supplier: ENZO LIFE SCIENCES

Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.

Supplier: VWR Chemicals

The level of volatile organic solvents in pharmaceutical raw materials or finished product is defined and monitored in accordance with ICH guidelines. Residual solvents are classified according to their risk assessment classes. A selection of residual solvent standards is now available from Avantor.

Supplier: MP Biomedicals

2-Hydroxypropyl-beta-cyclodextrin are non-toxic solubilisers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states.

Supplier: Cayman Chemical

Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir. Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.

Supplier: ENZO LIFE SCIENCES

URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

Supplier: ENZO LIFE SCIENCES

Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

Supplier: ENZO LIFE SCIENCES

Cell permeable modulator of Ins(1,4,5)-P3-induced Ca²⁺ release. A prototype drug for a group of structurally related calcium channel blockers in human platelets. Has been shown, in the absence of other stimuli, to activate TRPV1, V2 and V3, but not TRPV4, V5 and V6 expressed in HEK 293 cells. Potentiates the effect of capsaicin, protons and heat on TRPV1. It was originally introduced as an IP3 receptor blocker and subsequently as an inhibitor of store-operated Ca²⁺ entry (75µM).

Supplier: Cytiva (Formerly Pall Lab)

Biodyne® Transfer Membranes offer high sensitivity and low background for enhanced detection and resolution. They are ideal for nucleic acid detection.

Supplier: ENZO LIFE SCIENCES

A potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50=6 nM). It efficiently blocks IGF-1R activity, reduces pAKT and pERK1/2, induces apoptosis in IGF-1R-positive tumor cells and causes complete tumor regression in xenografted and allografted mice. Picropodophyllin downregulates IGF-1R by interfering with the action of β-arrestin 1/MDM2. It causes tumor regression and attenuates invasiveness of uveal melanoma cells. It displays beneficial effects on tumor growth, angiogenesis, bone disease and survival in a mouse multiple myeloma model. It attenuates intimal hyperplasia after vascular injury. Inhibition of IGF-1R is non-competitive with ATP.

Supplier: MP Biomedicals

Rosmarinic Acid is a phenylpropanoid isolated from Labiatae herbs. The compound exhibits antiinflammatory activity and inhibits the proliferation of murine mesangial cells.

Supplier: MP Biomedicals

Dextran is a high molecular weight polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-->6) linkages. The remaining a(1-->3) linkages account for the branching of dextran. Dextran has long and hydrophilic spacer arms that improves the performance of immobilized proteins acting on macromolecules.

Supplier: Greiner Bio-One

PS, without lid. Streptavidin coated solid phases serve as reliable binding surfaces for all types of biotinylated molecules. Numerous ligands can be biotinylated simply and reliably, and due to the low molecular weight of biotin (244 Da), the functionality of the molecules is normally not impaired. Thus streptavidin-coated solid phases make it possible to simply and rapidly isolate, determine and quantify components from a reaction mixture. By immobilising the biotinylated substance, it is also possible to reproduce complete reaction chains on a streptavidin solid phase, for example, enzyme immunoassays, enzyme activity assays, DNA hybridisation techniques, quantification of PCR products, and receptor/ligand studies.

Supplier: SIGMA ALDRICH MICROSCOPY

Acriflavine also interacts with HIF-1α (hypoxia-inducible factor 1 α) and HIF-2α, and thereby suppresses dimer formation of HIF-1 and transcriptional function. It also has negative effect on tumor growth and vascularization. Acriflavine also exhibits trypanocidal, antibacterial and antiviral activities.

Supplier: MP Biomedicals

Dextran is a high molecular weight polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-->6) linkages. Dextrans with molecular weights greater than 10,000 behave as if they are highly branched. As the molecular weight increases, dextran molecules attain greater symmetry.

Supplier: ENZO LIFE SCIENCES

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.