209 Results for: "Formamide"

A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.

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N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine ≥97% (by non aqueous titration)

Supplier: ENZO LIFE SCIENCES

Heavy metal chelator.

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Rockout ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

A cell permeable, selective, and ATP-competitive inhibitor of Rho kinase (ROCK) activity (IC50=25µM). Does not inhibit the activation of Rho nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be less potent than Y-27632.

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Pesticide reference standard, 2’,4’-Formoxylidide-d6, neat, Honeywell Fluka™

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

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HA14-1 ≥95% (by 1H-NMR)

Supplier: ENZO LIFE SCIENCES

Bcl-2 ligand

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Fingolimod hydrochloride ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A2 independently of sphingosine 1-phosphate receptors.

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SC-560 ≥98%

Supplier: ENZO LIFE SCIENCES

Selective COX-1 inhibitor (IC50=9nM). Shows 700-fold more selectivity over COX-2 (IC50=6.3µM). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2, and dermal PGE2 production. Orally active in rat.

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Sp-5,6-dichloro-cBIMPS ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

PKA activator.

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Anandamide ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

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Pharmaceutical analytical standard, 4-Formylaminoantipyrine-d3, reference material, Honeywell Fluka™

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

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UCN-01 (from Streptomyces sp. MST-AS5345) ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.

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Olomoucine II ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.

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VWR®, Residual solvents Class 2 according to Ph. Eur. Version 10

Supplier: VWR Chemicals

The level of volatile organic solvents in pharmaceutical raw materials or finished product is defined and monitored. Residual solvents are classified according to their risk assessment classes. A selection of residual solvent standards is now available from Avantor.

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N-(6-Aminohexyl)-5-chloro-1-naphthalenesulphonamide hydrochloride ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Binds to calmodulin, inhibiting Ca²⁺-calmodulin-regulated enzyme activity. It inhibits the Ca²⁺/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=25 µM). Cell permeable.

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Reveromycin A (from Streptomyces sp. MST-AS5344) ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Antibiotic. Dominant analog of the reveromycin complex. Inhibitor of the mitogenic activity of epidermal growth factor (EGF). G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Displays antiproliferative as well as potent antifungal activity. Induces apoptosis in osteoclasts thus inhibiting bone resorption.

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N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulphonamide ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.

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Arachidonic acid ≥99% (by TLC) (20:4, n-6)

Supplier: ENZO LIFE SCIENCES

Precursor to a large family of eicosanoids. Acts as a second messenger independent of metabolism. Retrograde messenger in long-term potentiation in the nervous system. Inhibits ras-GAP. Activator for several protein kinase C (PKC) isotypes.

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5,6-Dichlorobenzimidazole-1-β-D-Ribofuranoside ≥97% (by TLC)

Supplier: ENZO LIFE SCIENCES

DRB is a potent and specific inhibitor of casein kinase II (CKII, IC50~6 µM). It has been used to inhibit RNA polymerase II mediated-transcription which may be dependent on CKII and its interaction with ATF-1.

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Pharmaceutical analytical standard, (R,R)-Formoterol tartrate, reference material, Honeywell Fluka™

Supplier: Honeywell Chemicals

High quality inorganic and organic reference materials produced according to ISO 9001.

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9(S)-HODE ≥98%

Supplier: Cayman Chemical

9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals. It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidised LDL particles.

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Betaine enhancer solution 5 M (5X) for PCR

Supplier: VWR Chemicals

Betaine enhancer is especially effective when used with high GC-rich regions or templates with a high degree of secondary structures. It has a decreasing effect on the primer melting temperature.

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Galiellalactone (from unidentified fungus MST-FP1888) ≥95% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.

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8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer sodium salt ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP.

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K-252b ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).