Supplier: Boster Bio

CIITA is a human gene which is mapped to 16p13. This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. Also, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.

Supplier: Thermo Orion

These low maintenance ROSS pH electrodes offer unmatched benefits that users will not find in any other pH electrode. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.

Supplier: Cytiva

illustra™ Hot Start Mix, Ready-To-Go™ is a pre-formulated and pre-dispensed, freeze-dried PCR reagent mix, including high quality PuReTaq™ DNA polymerase and a hot start activator protein, for increased specificity and reproducibility of PCR amplifications. The Ready-To-Go™ beads are provided in either 0,5 or 0,2 ml tubes that are compatible with most thermal cyclers.

Supplier: Thermo Fisher Scientific

The Thermo Scientific™ F1-ClipTip™ pipette features interlocking technology to ensure secure tip attachment. The pipettes work exclusively with Thermo Scientific ClipTip pipette tips, providing a unique tip interface that locks the tip in place, and ensures a complete seal with minimal tip application and ejection forces. Tips are locked firmly in place and will not fall off.

Supplier: ProSci Inc.

This antibody recognises a protein of 56 kDa, identified as cytokeratin 6 (CK6) or Keratin 6. In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express Cytokeratin 6 and 16. Keratin 6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of Cytokeratin 6 is particularly associated with differentiation.

Supplier: ProSci Inc.

This mAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer's cells of the liver and Langerhan's cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.

Supplier: Priorclave

These versatile autoclaves are fully equipped for use in laboratories throughout the food, drink, dairy, health and pharmaceutical industries and offer a wide range of options and accessories to further improve their performance to suit individual load types. This flexibility is enhanced by the TACTROL™ microprocessor control system, specially developed for laboratory autoclaves, with progamming ranging from simple cycles to fully featured multi-program operation with logged records. All Priorclaves come complete with Biomaster antimicrobial coating, helping improved laboratory hygiene; it is effective against all bacteria and fungi including MRSA and therefore helps minimise the risk of cross contamination.

Supplier: Thermo Fisher Scientific

Pierce silver stain for mass spectrometry is a complete kit for rapid and ultra-sensitive silver staining of proteins in polyacrylamide gels and efficient destaining of excised gel pieces for mass spectrometry analysis. This kit enables both first-time and experienced users to achieve consistent and reliable staining using high, low, and gradient-percentage gels in 1D and 2D formats. The optimised staining method ensures extremely sensitive staining while minimizsing covalent crosslinking of protein to the gel matrix, which can inhibit protein recovery. The destaining reagents facilitate complete removal of silver from stained protein bands and maximum protein recovery for subsequent mass spectrometry analysis.

Supplier: VWR Chemicals

Plasmid Miniprep Kit I for the easy, quick and efficient extraction of highly pure plasmid DNA. Isolate up to 30 µg of high quality plasmid DNA from 1 to 5 ml bacterial cultures in 30 minutes or less. Plasmid DNA obtained with peqGOLD Plasmid Miniprep kits can directly be used for a wide range of downstream applications.

Supplier: VWR Chemicals

Purifies DNA bands 70 bp to 20 kb in length from agarose gels. The DNA band of interest is excised from the gel, dissolved in binding buffer, and efficiently processed in a peqGOLD DNA column. >90% recovery. Elution volume: 30 to 50 µl.

Supplier: Portwest

These multi use high visible bodywarmer vests are specially designed for those who will not compromise on style, comfort, protection and performance. These garments are designed to keep warm, dry and visible in all conditions. The 300D Oxford Industry High Visibility provides comprehensive range of single and combination garments in a highly durable and cleverly designed innovative styles.

Supplier: Thermo Orion

This electrode with built-in temperature sensor is ideal for any application where the use of metallic reference electrodes would contaminate the samples. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.

Supplier: KNICK

This portable Memosens-based instrument for the analysis of liquids can measure pH/ORP, conductivity (conductive/inductive), oxygen (amperometric/optical) and temperature and features direct printer control. A printer for immediate printing of the calibration record (GLP compliant) can be directly connected to the micro USB port. Waterproof according to IP 66/IP 67.

Supplier: Thermo Orion

This pH electrode is ideal for measuring micro volume samples. A PTFE protective sleeve over the glass stem provides greater durability than conventional micro pH electrodes and allows pH and temperature measurement of samples in 384 well plates or samples.
Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.

Supplier: Thermo Orion

This Triode™ electrode has a built-in temperature sensor allowing users to measure pH and temperature with only one electrode. Ideal for complex samples, such as biological media, foods and pharmaceuticals. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.

Supplier: bimos

Apart from special hygiene features, a laboratory chair must always be ready for use at changing places of work. It should take up a minimum of space yet still offer maximum ergonomics and seating comfort so as to guarantee precise and concentrated work over longer periods of time. Labster is ideal for everyday use in the laboratory.

Supplier: OMEGA BIO-TEK

The Mag-Bind® cfDNA Kit CE IVD is designed for rapid and reliable isolation of circulating cell-free DNA from 1 to 4 ml plasma/serum samples.

Supplier: Biotium

Phalloidin is a toxin isolated from the deadly Amanita phalloides mushroom. It is a bicyclic peptide that binds specifically to F-actin. Fluorescent conjugates of phalloidin are convenient tools to investigate the distribution of F-actin in fixed and permeabilised cells or tissue sections. One unit (U) of phallodin is sufficient to stain one sample (200 µl staining volume). A highly selective actin filament stain for fixed and permeabilised cells. Labeled phalloidins have similar affinity for both large and small filaments.

Supplier: ProSci Inc.

This antibody recognises a polypeptide of ~6.5 kDa, identified as Estrogen Inducible Protein pS2. The antibody's epitope is localized between amino acids 57-84. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. Estrogen Inducible Protein pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for estrogen inducible protein pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. It is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that estrogen inducible protein pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

Supplier: HIRSCHMANN

The rotarus® peristaltic pump series has a selection of different motors, varying housing safety classes and intelligent control of delivery volumes, covering a broad spectrum of application areas in the laboratory or industry.

Supplier: Thermo Orion

This combination pH electrode helps users to precisely conduct pH determinations. Its convenient flat surface tip measures pH in soft, moist surfaces both solid and semi-solid such as agar gel plates, meats, bread dough and similar samples. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.

Supplier: Thermo Orion

This general purpose, semi-micro tipped combination electrode with top-performance glass body can be used for precise pH determinations in micro volume samples. Compared to conventional electrodes, the proven ROSS reference system exhibits superior stability in measurements, faster response, greater accuracy and precision when measuring samples that vary in temperature or when calibrating in temperatures that differ from the samples.

Supplier: GRANT INSTRUMENTS

A range of eco-friendly, refrigerated/heating circulating baths with an intuitive user-interface and sleek design. Units offer significant running cost savings whilst delivering powerful cooling when needed. Choice of 2 models with temperature range of –25 to +150 °C (model dependent*). Ideal for applications in pharmaceutical, education, industrial and life science areas for use with mini pilot plant reactors, cooling rotary evaporators, replacing running tap water cooling, immersing small samples, photometry, chromatography systems, sample preparation, general cooling, reaction chemistry, temperature control, semi-conductor manufacturing, rheometry, refractometry and electrophoresis cooling.

Supplier: VWR Chemicals

The peqGOLD DNase I Digest Kit is optimised for use with peqGOLD RNA extraction protocols. Normally DNase I digestion is not required for RNA purified with peqGOLD RNA Mini Columns as our silica-based spin column technology efficiently removes the majority of DNA without enzymatic digestion. However, certain sensitive RNA applications may require further DNA removal.

Supplier: MP Biomedicals

FastRNA® Pro Blue Kit is used to isolate total RNA from gram positive and gram negative bacteria. Isolated RNA is suitable for RT-PCR analysis and other downstream applications.

Supplier: MP Biomedicals

Agarose is a natural polysaccharide isolated from agar or agar-bearing marine algae. Its physical and chemical properties are particularly suited for use as a gel medium for diffusion and electrokinetic movement of biomolecules. Agarose is essentially biologically inert and forms relatively clear, transparent gels. Agarose based gels offer several advantages: High gel strength permits use of low concentrations. The macroporous nature of the gels allows rapid diffusion of high molecular weight molecules. Agarose is Non-toxic. Agarose gels are thermally reversible facilitating sample recovery. Staining and destaining may be done rapidly with minimal background. Because agarose forms macroporous gels that are electrically nonionic, it is an excellent medium for Isoelectric Focusing (IEF). A selection of different formulated agaroses with specific qualities for unique applications are available from MP.
Multipurpose Agarose is a versatile high gel strength agarose, especially designed for a wide range of molecular biology techniques. It is used for resolution of fragments over a large size range from 200 bp up to 50 kb by conventional electrophoresis. It is suitable for use in pulsed field gel electrophoresis and for blotting assays.
High gel strength agarose, especially designed for a wide range DNA. Versatile – separate fragments from 200 bp up to 50 kb by conventional electrophoresis. Concentrations between 0.4% and 6%. Multipurpose Agarose features the highest gel strength available, allowing 0.4 - 0.5% agarose gels. Significantly decreases electrophoresis times. Improves separation of very large fragments. Dissolves easily in a microwave.

Supplier: Heidolph Instruments GmbH & Co.KG

Powerful electronic stirrers that feature a smooth start operation which prevents spills and splashing media. The speed ramps up slowly until set speed has been reached. Both models feature safe start and stop of operation via an intuitive glass slide touch panel to avoid accidental start-up. An overtemperature sensor shuts off the unit in dangerous heat-up situations, ideal for unattended continuous operation. All units are designed for continuous 24-hour operation, including challenging high viscosity applications in polymer research. High torque levels give better mixing results in less time, maintenance-free motors reduce repairs and down time. Hei-TORQUE Value 400 and Hei-TORQUE Precision 400 units have two speed gears.

Supplier: KNICK

These versatile, portable instruments can measure pH, ORP, conductivity and dissolved oxygen (optical). Thanks to their robustness and large selection of suitable sensors, they are suitable for both laboratory and process applications. Waterproof according to IP 66/IP 67.

Supplier: ProSci Inc.

ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Supplier: MP Biomedicals

FastRNA® Pro Red Kit is used to isolate total RNA from yeast and fungi. Isolated RNA is suitable for RT-PCR analysis and other downstream applications