14670 Results for: "ENZO LIFE SCIENCES"

Highly sensitive Total PSA ELISA kit enabling detection of Total PSA in human serum, plasma, urine, and tissue culture media samples in just 2,5 hours.

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Melatonin ELISA kit

Supplier: ENZO LIFE SCIENCES

Ultra-sensitive Melatonin ELISA kit enabling detection of Melatonin in saliva, serum, plasma, and fruit homogenates in just 2 hours.

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VEGF (Human), ELISA kit

Supplier: ENZO LIFE SCIENCES

Ultra-sensitive ELISA kit for the quantitative detection of human VEGF with 100% cross reactivity to VEGF 165 and negligible cross-reactivity to VEGF 121.

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Anti-HSP60 Goat Polyclonal Antibody

Supplier: Enzo Life Sciences

Hsp60 is a member of the chaperonin family of heat shock proteins, with homologs functioning in the cytosol and mitochondria to fold nascent and aggregated proteins. Hsp60 is the eukaryotic homolog of the E. coli GroEL protein, and forms a multimeric complex in the mitochondria with Hsp10 (Cpn10) to form a large central cavity in which ATP-dependent protein folding takes place. TRiC/CCT, a eukaryotic relative of Hsp60, is expressed in the cytosol and participates in the folding of actin and tubulin substrates, but lacks any association with an Hsp10-like co-factor.

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Anti-HSPA8 Rat Monoclonal Antibody

Supplier: Enzo Life Sciences

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

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Substance P ELISA kit

Supplier: Enzo Life Sciences

Highly sensitive Substance P ELISA kit enabling detection of Substance P in plasma, serum, saliva, urine, and supernatants in just 3 hours.

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Anti-TAPBP Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Anti-TAPBP Rabbit Polyclonal Antibody

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Human recombinant HSP90beta (from E. coli)

Supplier: Enzo Life Sciences

Produced in E. coli.

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Anti-HSP90 Rat Monoclonal Antibody (Biotin) [clone: 16F1]

Supplier: Enzo Life Sciences

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Mouse recombinant HSP70-A1 (from E. coli)

Supplier: Enzo Life Sciences

Produced in E.coli.

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N(5)-(1-Iminoethyl)-L-ornithine HCl ≥95% (by TLC)

Supplier: Enzo Life Sciences

L-NIO is approximately 5 times more potent as an inhibitor of endothelial cell NO synthase than other arginine analogs such as L-NAME and L-NMMA. It inhibits NO production in endothelial cytosol (IC50=0.5µM), inhibits acetylcholine induced relaxation of rat aorta rings (IC50=2µM) and causes a dose-dependent increase in mean arterial blood pressure (EC50=19.5 mg/kg) in the rat. The product is not sterile.

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Sulforhodamine multiCaspase activity kit

Supplier: Enzo Life Sciences

The Sulforhodamine Multi-Caspase Activity Kit detects apoptosis through the covalent binding of a red fluorescent probe to active caspase enzymes in living cells. The sulforhodamine-labeled caspase inhibitor probe (SR-VAD-FMK; excitation at 550 nm and emission at 595 nm), comprising a sulforhodamine derivative of valylalanylaspartic acid fluoromethyl ketone (VAD-FMK), covalently binds to the reactive cysteine (Cys 285) on the large subunit of active caspase heterodimers

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(+)-7-Octylindolactam V ≥99%

Supplier: Enzo Life Sciences

A biologically inactive isomer, which may be used as a negative control.

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Anti-MC3R Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

The melanocortin receptors are members of the G protein-coupled receptor superfamily. Their ligands, the melanocortins, are peptides consisting of µ-, β- and γ-melanocyte stimulating hormone and adrenocorticotropic hormone. MC3R binds all melanocortins with equal affinity. Agouti-related protein (AGRP) is the high affinity endogenous antagonist of MC3R. It is expressed in the brain, placenta, and gut tissues, but not in the adrenal cortex or melanocytes.

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Glibenclamide ≥98%

Supplier: Enzo Life Sciences

K⁺ channel blocker.

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Myriocin ≥98% (by TLC)

Supplier: Enzo Life Sciences

Palmitoyltransferase inhibitor

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Anti-ADAM12 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Host: Rabbit

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Anpirtoline ≥99% (by HPLC), white solid

Supplier: Enzo Life Sciences

Serotonin receptor ligand.

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Human recombinant MKP-1/p38 complex (from insect cells (Sf9))

Supplier: Enzo Life Sciences

Produced in Sf9 cells.

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S-(4-Nitrobenzyl)-6-thioinosine ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Potent adenosine uptake inhibitor and nucleoside transport inhibitor (IC50= 4.6nM).

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SQ-29548 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Potent, selective thromboxane A₂ receptor antagonist. Shows inhibition of human platelet aggregation initiated by arachidonic acid (IC₅₀=12 nM) . Ki=7.9 nM for inhibition of [³H]-U-46619 binding to human platelet membranes.