Supplier: Liebherr

Freezer for integrated use with SmartFrost technology significantly reduces frost build-up in the interior and on frozen food, and thus reduces the times need to defrost the freezer, and its electricity consumption. The interior walls are particularly smooth and therefore easy to clean. SuperFrost is also energy-saving: if switch off function not done manually, it automatically deactivates itself after 65 hours.

Supplier: Bioss

Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.

Supplier: TIGER-VAC

HEPA-Filter for SSAT-6L #212303 for model SSAT-6L 1 * 1 Each

Supplier: Honeywell Chemicals

QUARTZ, SAND, ACID PURIFIED, 40-100 MESH 1 * 1 kg

Supplier: HICHROM

REGIS COLUM IAM DD2 10CM X 4.6MM ID 1 * 1 Each

Supplier: SCIENTIFIC INDUSTRIES ELMIS

Same great features of the Original Vortex-Genie® 2 in addition to programmability. These rugged and reliable vortex mixers have a durable motor, solid metal casing and rubber feet that prevent them 'walking'. The Vortex-Genie® Pulse is ideal for applications requiring more aggressive action than standard vortexing.

Supplier: Bioss

The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterised by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2, facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

Supplier: Bioss

Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).

Supplier: Sartorius Balances

The Cubis® II range has a modular design that to allows the customer to choose the components that suit the application area that is of interest. For the customer, this configurable concept delivers quality weighing, together with a high degree of flexibility, without having to invest in expensive equipment that has features that may never be required.

Supplier: LEY RUBBER

Stopper,red rubber,two hole,BS no.21 1 * 20 items

Supplier: GLEN DIMPLEX

LSFSR82UK, 82L benchtop spark-free laboratory fridge, +2 to +10C, digital, white 1 * 1 items

Supplier: VISTALAB TECHNOLOGIES

Nozzle filter replacement kit, 0.2-10ml,5/bag 1 * 5 items

Supplier: Bioss

Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).

Supplier: EPPENDORF

LOWER PART 0.5-10UL 1 * 1 items

Supplier: GLASWARENFABRIK KARL HECHT

TEST TUBE 75X16 MM SPECIAL DESIGN 1 * 1.000 items

Supplier: Basan

MOPHEAD TRAPEZE SPARK 40X10 CM 1 * 1 items

Supplier: SARSTEDT

MICRO TUBE 2.0ML STERILE SKIRTED TYPE I 1 * 1.000 items

Supplier: Amarell

THERMOMETER NS14 5/23 MOUNT L55MM 1 * 1 items

Supplier: HIRSCHMANN

Suction tube . 310 mm for em-dispenser up to 10ml 1 * 1 items

Supplier: Thermo Fisher Scientific

250x4.6mm 10u MOS, Hypersil Column 1 * 1 items

Supplier: DWK Life Sciences

VIAL CRIMP TOP CLEAR 55/20 MM 1 * 100 items

Supplier: witeg Labortechnik

Flask for collecting 10ml, with cylindrical needle valve,120x16mmmm,st14/23, acc. to schlenk, null

Supplier: Tecan

Genuine Tecan® 5000 µL disposable automation tips for Freedom EVO® Liquid Handling Arm™ (LiHa) or Fluent® Flexible Channel Arm™ (FC A). ANSI format, non-filtered, conductive. Tecan PURE purity level - tested and certified to be free of human DNA, d 1 * 240 items

Supplier: Thermo Orion

These bench top meters with pH/ISE, conductivity and Dissolved Oxygen/RDO modules meet the most challenging applications for pH, ion concentration, conductivity, dissolved oxygen and temperature. The meters offer interchangeable measurement modules that allow multiple users to customise four separate channels to meet their specific requirements.

Supplier: R L ENTERPRISES

TROWEL 175MM 1 * 1 items

Supplier: Merck Millipore (Calbiochem‎)

Protease Inhibitor Cocktail Set I (10Vl = 1X10 Lyo. Ml) 1 * 1 Ampoul

Supplier: MARKET SOURCE PART PROCESS

S-Trap 96-well Mini Plate 1 * 3 items

Supplier: EPPENDORF

Calibration according to ISO 17025 including Preventive Maintenance 1 * 1 items

Supplier: Bioss

Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.

Supplier: MOLECULAR DEVICES

The SpectraMax® i3x multi-mode microplate reader is a configurable, versatile microplate reader that evolves with your future needs and allows you to investigate every aspect of a cellular pathway. The SpectraMax i3x microplate reader measures absorbance, luminescence and fluorescence as standard, and provides the flexibility to add novel detection capabilities without the need for service engineers or costly downtime - it grows with you as your research evolves.