Supplier: ProSci Inc.

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six genes which encode the structurally similar proteins: Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, 3B has little elastolytic activity. Like most of the human elastases, 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. It may also function in the intestinal transport and metabolism of cholesterol. Elastases 3A/B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Supplier: Antibodies.com

Mouse Retinoic acid Receptor alpha ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse Retinoic acid Receptor alpha in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Human PGC1 alpha ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human PGC1 alpha in serum, plasma, and other biological fluids.

Supplier: ProSci Inc.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Supplier: Antibodies.com

Human IL-18R beta/IL-18RAP ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human IL-18R beta/IL-18RAP in serum, plasma, and other biological fluids.

Supplier: ProSci Inc.

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.

Supplier: Portwest

A great value addition to the multi-protection range, the S774 jacket is a lightweight, unpadded garment hosting a multitude of functional features and benefits.

Supplier: BROTHER

The Brother PT-P900Wc professional PC-connectable label printer with integrated Wi-Fi helps you create customized, durable labels in many colour combinations and widths on your PC, Mac, tablet or smartphone then print using USB or Wi-Fi. This feature-rich, high-speed, high-resolution label printer lets you add barcodes, logos, images, frames and text to your labels and link to existing data in your spreadsheet to easily print many labels at once.

Supplier: EPPENDORF

Eppendorf twin.tec® real-time PCR plates, designed for low-volume qPCR, utilise white wells to enhance fluorescent light reflection, improving sensitivity and reproducibility in assays for reliable results.

Supplier: Portwest

A classic jacket with good fit to streamline and reduce the bulkiness women often feel in a fourseason jacket. The longer line back panel and discreet waist adjustment make this a contemporary silhouette and give a flattering smooth front jacket.

Supplier: THERMO OWL SCIENTIFIC

The Owl™ B2 EasyCast™ mini horizontal gel system provides flexibility in a small footprint and is available with or without buffer exchange ports. The Owl™ B3 with built-in recirculation system prevents formation of pH and ionic gradients for high resolution and uniform reproducible results. The Owl™ B3 is ideal for long runs, multiple sample sets or RNA gels. It also eliminates uneven migration, band distortion or disassociation of pH dependent glycoxylated RNA molecules that can result when ionic depletion occurs. As the recirculation system is built into the buffer chamber, no external pumps, tubing or stirring bars are required.

Supplier: Mettler - Toledo

Not only do these meters measure pH and ORP with classical sensors, but they also support pH measurement with ISFET technology. The instruments can effectively cope with complex applications and stringent requirements in regulated markets as well as with routine measurement tasks in laboratories.

Supplier: Portwest

These overalls are made from 300D Oxford Weave fabric (300 denier polyester yarn) which features a high abrasion and tear resistance. The PU coating on the inside makes the fabric durable and waterproof, while the outer has a water- and stain-repellant coating which helps keep the garment clean. Ideal for use in dark, cold and wet conditions.

Supplier: ProSci Inc.

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Supplier: Portwest

These premium jackets provide super comfort in all weathers and specially engineered for maximum performance. Waterproof and breathable to the highest standards, these jackets boast a multitude of features including six pockets for convenient storage and a full length superior two-way zip fastening.

Supplier: Portwest

Contemporary work jacket made from a soft knitted fleece fabric. Reinforced shoulders and back panels offer added durability in heavy-use areas. Interchangeable zip pullers in blue, red and lime green are supplied for easy integration of corporate colours. Designed with a modern fit, this jacket hosts a range of practical features including a longer back length, a rubber zip puller and multiple pockets.

Supplier: ProSci Inc.

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity.

Supplier: ProSci Inc.

EndoG Monoclonal Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans. EndoG also cleaves DNA in vitro.

Supplier: ProSci Inc.

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Supplier: ProSci Inc.

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Supplier: Portwest

The DX4 zipped hoodie is innovative and technical with a two-faced fabric that provides lightweight warmth and unrestricted movement. Two zipped chest and side entry pockets offer plenty of secure storage space. The full zip on the front has a rubber puller for easy grip and the adjustable hood provides a close fit. A contemporary option for the modern worker.

Supplier: Hach

8350 Combination pH sensor, 3/4 , analogue, for corrosive media 1 * 1 items

Supplier: LP ITALIANA

CONICAL TUBE WITH LABEL WITH YELLOW CAP 1 * 2.000 items

Supplier: VICI JOUR RESEARCH

FILTER SS ECONOMY MOBIL PHASE 10UM 1 * 2 items

Supplier: VICI JOUR RESEARCH

TUBING, PREMIUM, SS, 1/16'' OD X 1.00 MM 1 * 3 m

Supplier: Epredia

Microslide Superfrost Print 90 yellow glass cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: ASATEX

Polypropylene Lab -coat white / PKI 50g/qm Collar, press buttons,2 pockets, antistatic 1 * 50 items

Supplier: Epredia

Microslide Superfrost 45 blue glass with box cello ISO 8037/1 1,0mm 1 * 2.000 items

Supplier: EPPENDORF

Eppendorf Deepwell plates 96-well, 1000 µl offer efficient sample handling with features like OptiTrack® matrix for rapid identification and g-Safe® technology for stability during centrifugation. SafeCode variants provide secure three-level coding, including error correction for reliable identification, ensuring flexibility and accuracy in experimental workflows.

Supplier: ProSci Inc.

Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.